1228079-29-5

Basic information

• Product Name: tert-Butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate
• Synonyms: 1228079-29-5;tert-Butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate;N-BOC-1-OXO-1,3-DIHYDROSPIRO[INDENE-2,4'-PIPERIDINE];tert-butyl 3-oxospiro[1H-indene-2,4'-piperidine]-1'-carboxylate;MFCD22689932;SCHEMBL1912719;DTXSID80633416;SB32040;AS-38652;SY253749;CS-0136145;EN300-7412116;Z1508691399;tert-Butyl1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate;tert-Butyl 1-oxo-1,3-dihydro-1'H-spiro[indene-2,4'-piperidine]-1'-carboxylate;1 inverted exclamation mark -Boc-spiro[indene-2,4 inverted exclamation mark -piperidin]-1(3H)-one;Spiro[2H-indene-2,4'-piperidine]-1'-carboxylic acid, 1,3-dihydro-1-oxo-, 1,1-dimethylethyl ester
• CAS NO: 1228079-29-5
• Molecular Weight: 0
• Mol File: 1228079-29-5.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: tert-Butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(1228079-29-5)
• EPA Substance Registry System: tert-Butyl 1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate(1228079-29-5)

Safety Data

• Hazardous Substances Data: 1228079-29-5(Hazardous Substances Data)

Upstream product

• 83-33-0 inden-1-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 136080-25-6 spiro[indene-2,4’-piperidin]-1(3H)-one 
• 100-39-0 benzyl bromide 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 167263-10-7 4-benzyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 118753-70-1 N-(tert-butyloxycarbonyl)bis(2-chloroethyl)amine 
• 159635-50-4 Bis-(2-bromo-ethyl)-carbamic acid tert-butyl ester 

Downstream Products

• 2245085-40-7 tert-butyl (S)-1-(((R)-tert-butylsulfinyl)amino)-1,3-dihydrospiro[indene-2,4’-piperidine]-1‘-carboxylate 
• 2306254-23-7 (S)-1,3-dihydrospiro[indene-2,4′-piperidine]-1-amine dihydrochloride 
• 2245085-40-7 tert-butyl (S)-1-((S)-tert-butylsulfinylamino)-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylate 
• 2245085-41-8 (S)-N-((S)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-yl)-2-methylpropane-2-sulfinamide 
• 185525-49-9 spiro[indene-2,4’-piperidin]-1(3H)-one hydrochloride salt 
• 6841-89-0 1,3-dihydrospiro[indene-2,4'-piperidine] 

Relevant articles and documents

REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.

Compound serving as SHP2 inhibitor and application thereof

The invention belongs to the field of medical chemistry, relates to a compound serving as an SHP2 inhibitor and an application of the compound, and particularly provides a compound shown in a formula (I) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug of the compound, processes for the preparation, pharmaceutical compositions containing these compounds and the use of these compounds or compositions for the treatment of SHP2 mediated diseases.

SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF

Provided herein are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.