1612893-78-3

Basic information

• Product Name: 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride
• Synonyms: 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride
• CAS NO: 1612893-78-3
• Molecular Weight: 371.826
• Mol File: 1612893-78-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride(1612893-78-3)
• EPA Substance Registry System: 5-(4-guanidinophenyl)-N-(m-tolyl)isoxazole-3-carboxamide hydrochloride(1612893-78-3)

Safety Data

• Hazardous Substances Data: 1612893-78-3(Hazardous Substances Data)

Upstream product

• 1612893-54-5 5-(4-guanidinophenyl)isoxazole-3-carboxylic acid methyl ester hydrochloride 
• 100-19-6 (4-nitrophenyl)ethanone 
• 908802-68-6 ethyl 5-(4-amino-phenyl)isoxazole-3-carboxylate 
• 159670-70-9 ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate 
• 54808-56-9 4-(4-nitrophenyl)-2,4-dione-butyric acid ethyl ester 
• 1612893-55-6 5-(4-guanidinophenyl)isoxazole-3-carboxylic acid hydrochloride 
• 108-44-1 1-amino-3-methylbenzene 

Relevant articles and documents

Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors

Human acrosin is an attractive target for the discovery of novel male contraceptives. Isoxazole derivative ISO-1, a small-molecule weak human acrosin inhibitor, was used as the starting point for lead optimization. After two rounds of structure-based inhibitor design, a highly potent inhibitor B6 (IC50 = 1.44 μM) was successfully identified, which showed good selectivity over trypsin and represents one of the most active human acrosin inhibitors up to date.