15971-95-6

Usage

InChI:InChI=1/C10H16O3/c11-9(6-7-10(12)13)8-4-2-1-3-5-8/h8H,1-7H2,(H,12,13)

Upstream product

• 108-30-5 succinic acid anhydride 
• 931-50-0 cyclohexylmagnesium bromide 
• 1123-86-0 cyclohexyl ethyl ketone 
• 108-85-0 1-bromocyclohexane 
• 17615-02-0 1-cyclohexyl-2-(triphenyl-λ⁵-phosphanylidene)ethan-1-one 
• 10035-86-6 S-ethyl cyclohexanecarbothioate 
• 16076-59-8 γ--γ-ketobuttersaeure-methylester 
• 23684-13-1 4-oxo-hex-5-enoic acid methyl ester 
• 931-51-1 cyclohexylmagnesiumchloride 
• 54966-52-8 4-cyclohexyl-4-oxo-butyric acid ethyl ester 
• 82084-27-3 4,5-dihydro-2-cyclohexylfuran 
• 626-62-0 Cyclohexyl iodide 
• 17615-04-2 Triphenyl-(hexahydrobenzoyl-methoxycarbonyl-methyl-methylen)-phosphoran 
• 14886-54-5 methyl 4-oxo-4-cyclohexylbutanoate 

Downstream Products

• 14886-54-5 methyl 4-oxo-4-cyclohexylbutanoate 
• 18930-19-3 1-cyclohexylbutane-1,4-diol 
• 66662-25-7 4-cyclohexyl-4-oxobutanal 
• 15972-17-5 5-cyclohexyl-dihydrofuran-2(3H)-one 
• 1444311-45-8 2-[3-cyclohexyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetic acid 
• 1444311-29-8 ethyl 2-[3-cyclohexyl-5-(3-methoxybenzyl)-6-oxopyridazin-1(6H)-yl]acetate 
• 1444311-18-5 6-cyclohexyl-4-(3-methoxybenzyl)pyridazin-3(2H)-one 

Relevant academic research and scientific papers

Efficient regioselective oxetane formation during photochemical transformation of spiro[4. n]-2,5-Diones

The irradiation of a variety of spirodiones (3) in the presence of carbonyl compounds led to the formation of oxetanes (6) regioselectively, which upon hydrolysis afforded the corresponding ketoacids (7) in excellent yields.

Metallacyclische Acyl-carboxylate des Nickels: Reaktivitaet der Acylgruppe und Synthesepotential bei Kreuzkopplungsreaktionen mit Alkylhalogeniden

2-Cyclohexene-1,2-dicarboxylic acid-anhydride reacts with electron-rich nickel(0) centres to form nickel(0) complexes, whereas the isomeric 4-cyclohexene-1,2-dicarboxylic acid-anhydride reacts with ring opening of the anhydride to yield thermally stable acyl-carboxylato-nickel(II) compounds.The structure of a typical compound with (TMED)Ni0 as a complex fragment was determined by single crystal X-ray structural analysis, the crystal also containing the product of CO-elimination, the nickelalactone.The cross-coupling reaction of metallacyclic acyl-carboxylato complexes of Ni with R-X can be used for the formation of side chains of steroids containing γ-ketocarboxylic acids.These compounds are interesting precursors for the preparation of analogues of vitamin D3 metabolites.

MODIFIED AMINE LIPIDS

The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.

Palladium(II)-Catalyzed C(sp 3)-H Activation of N,O-Ketals towards a Method for the β-Functionalization of Ketones

A method for the formal β-functionalization of aliphatic ketones via a palladium-catalyzed sp 3 C-H activation pathway is reported. An N,O-ketal directs an aliphatic C-H carbonylation to form γ-lactams which upon hydrolysis generate γ-keto carb

Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans

O-heterocycles bearing tetrasubstituted stereogenic centers are prepared via catalytic chemo- and enantioselective nucleophilic additions to ketoaldehydes, in which the ketone reacts preferentially over the aldehyde. Five- and six-membered rings with both aromatic and aliphatic substituents, as well as an alkynyl substituent, are obtained. Moreover, 2,2,5-trisubstituted and 2,2,5,5-tetrasubstituted tetrahydrofurans are synthesized with excellent stereoselectivities. Additionally, the synthetic utility of the described method is demonstrated with a three-step synthesis of the side chain of anhydroharringtonine.

SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE

The present invention relates to substituted amino-benzimidazoles of general formula (1) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (β-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4- dihydroquinazoline ring was identified by high-throughput screening for the inhibition of BACE-1. X-ray crystallography revealed that the exocyclic amino group participated in a hydrogen

THERAPEUTIC AGENT FOR DIABETES

A therapeutic agent for diabetes, which comprises a compound of the formula [I] wherein Xis a group of the formula wherein R4and R5are the same or different and each is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, and R6is a hydrogen atom or an amino-protecting group; R1is an optionally substituted alkyl having 1 to 5 carbon atoms, an optionally substituted alkenyl having 2 to 6 carbon atoms and the like, R2is a hydrogen atom, an optionally substituted alkyl having 1 to 5 carbon atoms and the like, R2' is a hydrogen atom, and R3is an optionally substituted alkyl having 1 to 5 carbon atoms and the like, a prodrug thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof. The compound of the present invention shows superior blood sugar decreasing action on the state of hyperglycemia, but does not affect the blood sugar when it is in the normal range or in the hypoglycemic state, which means that it is free of serious side effects such as hypoglycemia. Therefore, the compound of the present invention is useful as a therapeutic drug for diabetes and also useful as a preventive of the chronic complications of diabetes.

4-(trans-4-methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent

During an investigation of drugs for improving the β-cell response to glucose, we found that 4-cyclohexyl-4-oxobutyric acid selectively improved glucose-stimulated insulin release and glucose tolerance in both normal and diabetic rats. A series of 4-cyclo

A Synthesis of 4-Oxo Carboxylic Acids, 4-Oxo Aldehydes, and 1,4-Diketones from γ-Lactones

The α-methyldiphenylsilyl derivatives of γ-butyrolactone, γ-valerolactone, and the cis lactone of 2-hydroxycyclohexaneacetic acid have been reacted with Grignard reagents.The α-silylated lactones of γ-butyrolactone and γ-valerolactone react with a single equivalent of Grignard reagent to give a 2-substituted 4,5-dihydrofuran, which can be hydrolyzed and oxidized to 4-oxo carboxylic acids, 1,4-diketones, or 4-oxo aldehydes.The α-silylated fused lactone failed to react with ethylmagnesium bromide in refluxing tetrahydrofuran.An X-ray crystal structure of this silylated lactone indicated that this lack of reactivity is due to steric factors.