1598-89-6

Usage

Uses

Used in Pharmaceutical Industry:
3,3'-Bis(trifluoromethyl)benzhydrol is used as a reagent for the synthesis of pharmaceutical compounds, leveraging its ability to introduce trifluoromethyl groups into organic molecules, which can improve the stability and biological activity of the resulting pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical sector, 3,3'-Bis(trifluoromethyl)benzhydrol is employed as a building block for the development of agrochemicals, where the trifluoromethyl groups can enhance the performance and effectiveness of these compounds.
Used in Materials Science:
3,3'-Bis(trifluoromethyl)benzhydrol is used as a component in the creation of advanced materials, where its unique properties contribute to the development of materials with specific characteristics for various applications in science and industry.

InChI:InChI=1/C15H10F6O/c16-14(17,18)11-5-1-3-9(7-11)13(22)10-4-2-6-12(8-10)15(19,20)21/h1-8,13,22H

Upstream product

• 1868-00-4 3,3'-bis(trifluoromethyl)benzophenone 
• 402-26-6 3-(trifluoromethyl)phenylmagnesium bromide 
• 109-94-4 formic acid ethyl ester 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 454-89-7 3-Trifluoromethylbenzaldehyde 

Downstream Products

• 1868-00-4 3,3'-bis(trifluoromethyl)benzophenone 
• 1116366-14-3 α-ethenyl-α-[(3-(trifluoromethyl)phenyl)]-3'-(trifluoromethyl)benzenemethanol 
• 534617-71-5 chlorobis(3-(trifluoromethyl)phenyl)methane 
• 86845-35-4 3,3'-bis(trifluoromethyl)diphenylmethane 
• 2560-96-5 Di-<3.3'-bis-trifluormethyl-benzhydryl>-aether 
• 51339-23-2 bis<3-(trifluoromethyl)phenyl>methyl bromide 

Relevant academic research and scientific papers

Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates

Hydroxyphosphoric acids display the unique biological activities, and they have some attractive prospects as clinical drug moleculars. Herein, a new approach for the synthesis of γ-oxo-phosphonates (the precursor of hydroxyphosphoric acid) has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process. Most important, this transformation is avoid of the external oxidants, and occurs very well under the sunlight irradiation, meanwhile the γ-oxo-phosphonate was easily derivatized to obtain γ-hydroxyphosphoric acid, thus highlights the synthesis value of this method.

COMPOUNDS HAVING A FUNGICIDAL ACTIVITY, THEIR AGRONOMIC COMPOSITIONS AND USE THEREOF FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI

Compounds having general formula (I) with a high fungicidal activity and their use for the control of phytopathogenic fungi of important agricultural crops, are described.

MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF

Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.

Glycine transporter-1 inhibitors

The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

A formally zwitterionic ruthenium catalyst precursor for the transfer hydrogenation of ketones that does not feature an ancillary ligand N-H dunctionality

Fast and furious: Even without the assistance of an N-H donor ligand, the Ra complex shown in the scheme is a remarkably active precatalyst for the transfer hydrogenation of ketones in basic iPrOH (R,R′ = alkyl oraryl), providing near-quantitative yields within minutes and exhibiting consistently high turnover frequencies (104 to 105 h-1) for a diverse range of substrates. (Chemical Equation Presented).

Dications of fluorenylidenes. The relationship between redox potentials and antiaromaticity for meta- and para-substituted diphenylmethylidenefluorenes

Electrochemical oxidation of meta-substituted diphenylmethylidenefluorenes (3a-g) results in the formation of fluorenylidene dications that are shown to be antiaromatic through calculation of the nucleus independent chemical shift (NICS) for the 5- and 6-

Carbon Acidity. 66. Equilibrium Ion Pair Acidities of Substituted Diphenylmethanes in Cyclohexylamine

The pKCsCHA values are reported for a number of symmetrically meta- and para-substituted diphenylmethanes.The pKCsCHA values for the meta series (Me, 33.8; OMe, 32.7; F, 29.9; CF3, 28.9; Ph, 32.3; H, 33.4) give a normal Hammett plot with ρ = 9.69.The para series (Me, 35.1; OMe,37.6; Ph, 30.8; NMe2, 38.6; SPh, 28.8; CN, 23.0; SO2Me, 22.4) do not fit attempted correlations with ?, the Yukawa-Tsuno modifications, or dual substituent parameter approaches.Electron-donating groups are more anion destabilizing than in other reference systems. "Amphoteric" substituents, those that stabilize both anions and cations (phenyl, thio, etc.), cause special problems in generalized correlations.