1116366-14-3

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 1598-89-6 3,3'-bis(trifluoromethyl)benzhydrol 
• 1868-00-4 3,3'-bis(trifluoromethyl)benzophenone 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 1448819-51-9 4,4,4-trifluoro-1,2-di-[(3-trifluoromethyl)phenyl]-1-butanone 
• 1616781-69-1 3-(diphenylphosphoryl)-1,2-bis(3-(trifluoromethyl)phenyl)propan-1-one 
• 1116366-65-4 C₂₇H₁₈F₆O 
• 1116366-57-4 2,2-di(3-trifluoromethylphenyl)-3-(1-naphthylmethyl)oxirane 

Relevant academic research and scientific papers

Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates

Hydroxyphosphoric acids display the unique biological activities, and they have some attractive prospects as clinical drug moleculars. Herein, a new approach for the synthesis of γ-oxo-phosphonates (the precursor of hydroxyphosphoric acid) has been established through the semipinacol rearrangement tactic involved the photo-induced phosphorus radical process. Most important, this transformation is avoid of the external oxidants, and occurs very well under the sunlight irradiation, meanwhile the γ-oxo-phosphonate was easily derivatized to obtain γ-hydroxyphosphoric acid, thus highlights the synthesis value of this method.

Electrochemical Oxidative Aryl(alkyl)trifluoromethylation of Allyl Alcohols via 1,2-Migration

An electrochemical oxidative difunctionalization of allyl alcohols for the synthesis of β-trifluoromethyl ketones is achieved through a 1,2-migration process. A series of β-trifluoromethyl ketones can be facilely obtained utilizing CF3SO2

Copper-catalyzed trifluoromethylation-initiated radical 1,2-aryl migration in α,α-diaryl allylic alcohols

Not only symmetrical, but also unsymmetrical α,α-diaryl allylic alcohols are employed as substrates in the title reaction. A number of arenes and even heteroarenes underwent radical 1,2-aryl migration ("neophyl rearrangement") to produce α-aryl β-trifluoromethyl ketones. The preferential migration of electron-deficient aryl groups over electron-rich ones in unsymmetrical substrates supports the radical mechanism, which was further confirmed by DFT calculations. Copyright