1598387-33-7

Basic information

• Product Name: (4S)-3-((2S)-3,3-difluoro-2-methyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one
• CAS NO: 1598387-33-7
• Molecular Weight: 341.43
• Mol File: 1598387-33-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S)-3-((2S)-3,3-difluoro-2-methyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-3-((2S)-3,3-difluoro-2-methyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one(1598387-33-7)
• EPA Substance Registry System: (4S)-3-((2S)-3,3-difluoro-2-methyl-3-(trimethylsilyl)propanoyl)-4-phenyloxazolidin-2-one(1598387-33-7)

Safety Data

• Hazardous Substances Data: 1598387-33-7(Hazardous Substances Data)

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 184363-66-4 (4S)-4-benzyl-3-propionyl-1,3-oxazolidin-2-one 

Relevant articles and documents

Direct α-siladifluoromethylation of lithium enolates with ruppert-prakash reagent via Ci-F bond activation

The direct α-siladifluoromethylation of lithium enolates with the Ruppert-Prakash reagent (CF3TMS) is shown to construct the tertiary and quaternary carbon centers. The Ruppert-Prakash reagent, which is versatile for various trifluoromethylation as a trifluoromethyl anion (CF3 -) equivalent, can be employed as a siladifluoromethyl cation (TMSCF2+) equivalent by Ci-F bond activation due to the strong interaction between lithium and fluorine atoms. Reaching for Ruppert-Prakash: The direct α-siladifluoromethylation of lithium enolates with the Ruppert-Prakash reagent (CF3TMS) is shown to construct tertiary and quaternary carbon centers (see scheme). The Ruppert-Prakash reagent can be employed as a siladifluoromethyl cation (TMSCF2+) equivalent by Ci-F bond activation due to the strong interaction between lithium and fluorine atoms.