128740-14-7

Basic information

• Product Name: 6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE
• Synonyms: 6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE;6-Benzyl-1H-octahydropyrrolo[3,4-b]pyridine;6-Benzyl-octahydro-pyrrolo[3,4-b]pyridine 2HCl;Octahydro-6-(phenylMethyl)-1H-Pyrrolo[3,4-b]pyridine;1H-Pyrrolo[3,4-b]pyridine, octahydro-6-(phenylmethyl)-;6-Benzyl-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridine;Octahydro-6-(benzyl)-1H-pyrrolo[3,4-b]pyridine
• CAS NO: 128740-14-7
• Molecular Formula: C14H20N2
• Molecular Weight: 216.32
• Product Categories: pharmacetical;Heterocycle-Pyridine series
• Mol File: 128740-14-7.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 322℃
• Flash Point: 131℃
• Appearance: /
• Density: 1.049
• Vapor Pressure: 0.000283mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.99±0.20(Predicted)
• CAS DataBase Reference: 6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(128740-14-7)
• EPA Substance Registry System: 6-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRIDINE(128740-14-7)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 128740-14-7(Hazardous Substances Data)

Usage

Uses

Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine is an intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.

InChI:InChI=1/C14H20N2/c1-2-5-12(6-3-1)9-16-10-13-7-4-8-15-14(13)11-16/h1-3,5-6,13-15H,4,7-11H2

Upstream product

• 151636-48-5 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane L-(+)-tartrate salt 
• 1310-73-2 sodium hydroxide 
• 128740-14-7 8-benzyl-2,8-diazabicyclo[4.3.0]nonane 
• 151636-47-4 (S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane-D-tartrate 
• 151213-41-1 [1S,6R]-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane 
• 151636-46-3 (S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane tartrate salt 
• 1169974-48-4 C₁₆H₁₈N₂O₃ 
• 151213-40-0 (1S,6S)-2,8-diazabicyclo[4.3.0]nonane 
• 87-69-4 L-Tartaric acid 
• 4664-00-0 2,3-pyridinedicarboximide 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 100-46-9 benzylamine 
• 18184-75-3 6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 

Downstream Products

• 151213-42-2 [R,R]-2,8-diazabicyclo[4.3.0]nonane 
• 151213-43-3 [R,R]-8-benzyl-2,8-diazabicyclo[4.3.0]nonane 
• 159877-36-8 octahydro-pyrrolo[3,4-b]pyridine-1-carboxylic acid tert-butyl ester 
• 1438082-56-4 tert-butyl 6-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)octahydro-1H-pyrrolo[3,4-b] pyridine-1-carboxylate 
• 1438073-26-7 N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438073-44-9 N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(1-methylhexahydro-1H-pyrrolo[3,4-b]pyridine-6(2H)-yl)propoxy) quinazolin-4-amine 
• 1438073-80-3 N-(3-chloro-4-fluorophenyl)-6-(3-(1-ethylhexahydro-1H-pyrrolo[3,4-b]pyridin-6(2H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438084-39-9 6-benzyl-1-ethyloctahydro-1H-pyrrolo[3,4-b]pyridine 
• 186826-86-8 moxifloxacin hydrochloride 
• 151213-40-0 (1S,6S)-2,8-diazabicyclo[4.3.0]nonane 
• 151096-09-2 moxifloxacin 
• 151213-39-7 (S,S)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane-D-tartrate 
• 151636-48-5 (R,R)-8-benzyl-2,8-diazabicyclo[4.3.0]nonane L-(+)-tartrate salt 
• 158060-81-2 2,8-diazabicyclo[4.3.0]nonane 

Relevant articles and documents

Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment

A series of octahydropyrrolo[3,4-c]pyrroles were synthesized and evaluated by orexin 1 and 2 receptor (OX1 & 2R) antagonists assays. Compound 14l with potent OXR antagonist activity and suitable pharmacokinetic behavior was chosen to be investigated in an EEG study, which demonstrated effects of sleep promotion comparable to Suvorexant. Furthermore, the di-fluro substituted analogs exhibited reduced hERG inhibition while maintaining moderate potency.

Catalytic Transfer Hydrodebenzylation with Low Palladium Loading

A highly-efficient catalytic system for hydrodebenzylation reaction is described. The cleavage of O-benzyl and N-benzyl protecting groups was performed using an uncommonly low palladium loading (0.02–0.3 mol%; TON up to 5000) in a relatively short reaction time. The approach was used for a variety of substrates including pharmaceutically important precursors, and gram-scale deprotection reaction was shown. Transfer conditions together with easy-to-make Pd/C catalyst are the key features of this debenzylation scheme. (Figure presented.).

Pyrrolidines compound and its synthesis method (by machine translation)

A pyrrolidine compound and its synthetic method, will be dissolved in an organic solvent in the cyclic imide compound with hydrogen as a reducing agent of the reagent and a Lewis acid as a catalyst mixing, under the condition of refluxing to prepare the aromatic ring and fat ring pyrrolidines. Synthetic route of this invention is simple, efficient and economic, mild condition, wide applicability, to pyrrolidines compound at the later stage of industrial production will play a great role in promoting. (by machine translation)