159981-07-4

Upstream product

• 497847-36-6 N⁴-benzoyl-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]cytosine 
• 161424-49-3 2,3,5-tri-O-benzyl-4-O-p-nitrobenzoyl-L-lyxose dithiobenzylacetal 
• 161512-40-9 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-α,β-D-ribofuranose 
• 144950-26-5 2,3,5-tri-O-benzyl-L-lyxose dibenzyldithioacetal 
• 153439-75-9 2,3,5-tri-O-benzyl-D-ribose dibenzyldithioacetal 
• 158852-11-0 benzyl 2,3,5-tri-O-benzyl-1,4-dithio-D-ribofuranoside 
• 26661-13-2 4-N-benzoylcytosine 
• 64363-77-5 methyl 2,3,5-tri-O-benzyl-D-ribofuranoside 
• 497847-32-2 N⁴-benzoyl-1-[2-O-(2,4-dimethoxybenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]cytosine 
• 497847-35-5 1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-thio-β-D-ribofuranosyl]cytosine 
• 291758-13-9 (R)-1,4-anhydro-2-O-(2,4-dimethoxybenzoyl)-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-4-sulfinyl-D-ribitol 
• 161424-51-7 1-<2,3,5-tri-O-benzyl-4-thio-β-D-ribofuranosyl>-N₄-benzoyl-cytosine 

Downstream Products

• 159981-09-6 N⁴-benzoyl-1-[5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine 
• 93080-09-2 4'-thiocytidine 

Relevant academic research and scientific papers

4'-Thio-RNA: Synthesis, base pairing properties and interaction with dimerization initiation site of HIV-1

In the present paper, we describe the synthesis of a modified 9-mer oligonucleotide, 4'-S-r(UGUGCACCU) containing for the first time 4'-thio- guanosine units. This modified 9-mer was found to inhibit in vitro genomic RNA dimerization as well as the wild type RNA.

Synthesis and structural elucidation of 1-(3-C-ethynyl-4-thio-β-D-ribofuranosyl)cytosine (4′-thioECyd)

A practical synthesis of 1,4-anhydro-4-thio-D-ribitol (5) via 1,4-dibromo-1,4-dideoxy-2,3,5-tri-O-benzyl-L-lyxitol (12) is described. This method reduced our previous eleven step procedure starting from D-ribose by three steps. The Pummerer reaction of 1,

4'-Thio-β-D-oligoribonucleotides: Nuclease resistance and hydrogen bonding properties

The syntheses and the study of nuclease resistance and hydrogen bonding of modified oligoribonucleotides, i.e. 4'-thio-β-D-oligoribonucleotides (4'-S-RNA), are reported.

A new synthesis of some 4'-thio-D-ribonucleosides and preliminary enzymatic evaluation

A new synthesis of 4'-thioribonucleosides is presented together with the enzymatic evaluation of the adenosine analogues with respect to adenosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor 7 was obtained in good yield from D-ribose and fur