16000-10-5Relevant academic research and scientific papers
Nucleophilic acylation of α-haloketones with aldehydes: An umpolung strategy for the synthesis of 1,3-diketones
Singh, Santosh,Singh, Pankaj,Rai, Vijai K.,Kapoor, Ritu,Yadav, Lal Dhar S.
experimental part, p. 125 - 128 (2011/02/26)
The first example of N-heterocyclic carbene (NHC)-promoted intermolecular acylation of α-haloketones with aldehydes and α,β-unsaturated aldehydes (enals) is reported. The protocol involves carbonyl umpolung reactivity of aldehydes and enals in which the carbonyl carbon attacks nucleophilically on electrophilic terminal of α-haloketones to afford 1,3-diketones and α,β-unsaturated 1,3-diketones, respectively. Short reaction time, ambient temperature, operational simplicity, and high yields are the salient features of the present procedure.
NEW METHOD FOR PRODUCING α,β-UNSATURATED β-DIKETONES
Movchan, T. I.,Voloshanovskii, I. S.
, p. 1973 - 1976 (2007/10/02)
This paper proposes a new method for obtaining α,β-unsaturated acyclic β-diketones that differs from existing techniques in utilizing simple technology and giving high target product yields.
