1600501-10-7

Upstream product

• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 87613-34-1 1-methyl-2-phenyl-1H-indole-3-carbonitrile 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 16096-33-6 1-phenyl-1H-indole 

Relevant academic research and scientific papers

Site-Selective Electrochemical C-H Cyanation of Indoles

An electrochemical approach for the site-selective C-H cyanation of indoles employing readily available TMSCN as cyano source has been developed. The electrosynthesis relies on the tris(4-bromophenyl)amine as a redox catalyst, which achieves better yield and regioselectivity. A variety of C2- and C3-cyanated indoles were obtained in satisfactory yields. The reactions are conducted in a simple undivided cell at room temperature and obviate the need for transition-metal reagent and chemical oxidant.

Zinc-catalyzed direct cyanation of indoles and pyrroles: Nitromethane as a source of a cyano group

With nitromethane and diphenylsilane (Ph2SiH2), zinc triflate behaves as a Lewis acid catalyst for the cyanation of nitrogen-containing heteroarenes such as indoles and pyrroles. This is the first realization of the Lewis acid-catalyzed direct cyanation of a C(aryl)-H bond with no CN group-containing cyanating agent.