16096-33-6

Usage

Uses

Used in Chemical Synthesis:
1-PHENYL-1H-INDOLE is used as a precursor in the synthesis of other organic compounds, leveraging its unique structure to facilitate the creation of a variety of chemical entities.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-PHENYL-1H-INDOLE serves as a building block in the production of pharmaceuticals and agrochemicals, contributing to the development of new drugs and agricultural chemicals.
Used in Medicinal Chemistry:
1-PHENYL-1H-INDOLE is utilized in drug discovery and development within the field of medicinal chemistry, where its distinctive chemical structure and properties are harnessed to explore potential therapeutic applications and advance novel treatments.

InChI:InChI=1/C14H11N/c1-2-7-13(8-3-1)15-11-10-12-6-4-5-9-14(12)15/h1-11H

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 73425-20-4 1-phenylindoline-2-thione 
• 68394-64-9 1-phenyl-4,5,6,7-tetrahydro-1H-indole 
• 107-21-1 ethylene glycol 
• 122-39-4 diphenylamine 
• 120-72-9 indole 
• 462-06-6 fluorobenzene 
• 102-71-6 triethanolamine 
• 108-86-1 bromobenzene 
• 102-69-2 tri-n-propylamine 
• 563-79-1 2,3-Dimethyl-2-butene 
• 102-82-9 tributyl-amine 
• 41725-90-0 methyl 2-methylbut-2-enoate 
• 109-92-2 ethyl vinyl ether 

Downstream Products

• 132594-37-7 (1-phenyl-indol-3-yl)-glyoxylic acid dimethylamide 
• 75465-55-3 2-Brom-N-methyl-3-(1-phenyl-2-indolyl)maleinimid 
• 75465-54-2 2-Brom-3-(3-brom-1-phenyl-2-indolyl)-N-methylmaleinimid 
• 256-96-2 dibenzoazepine 
• 18434-12-3 1,2-diphenyl-1H-indole 
• 723-89-7 1-phenyl-indole-2,3-dione 
• 740815-36-5 2-(dicyclohexylphosphino)-N-phenylindole 
• 244090-32-2 1-phenylindole-3-carboxylic acid methyl ester 
• 244090-34-4 1-phenyl-1H-indole-3-carboxylic acid 

Relevant academic research and scientific papers

Hypervalent iodine in synthesis. 77. An efficient method for the synthesis of N-arylindoles by the copper-catalyzed N-arylation of indole with diaryliodonium salts

N-arylindoles were prepared in good yields by copper-catalyzed N-arylation of indole with diaryliodonium salts.

Unique CuI-pyridine based ligands catalytic systems for N-arylation of indoles and other heterocycles

Two pyridine-based ligands (N-((pyridin-2-yl) methyl) pyridin-2-amine) L1 and (N-((pyridin-2-yl) methylene) pyridin-2-amine) L2 are explored in present work which are inexpensive, effective and environmentally benign in their properties. These have been utilized for C-N cross coupling reaction resulting in N-arylation. The N-arylation of indole, imidazole and triazole have been successfully carried out with different aryl and heteroaryl halides using these ligands.

New polymer-bound haloarene chromium dicarbonyl isocyanide complexes: A successful study validating their use in solid-phase chemistry

New fluorobenzene chromium dicarbonylisocyanide complexes have been synthesized and evaluated in terms of their 'in solution' reactivity towards some nucleophiles. For the first time the polymer-bound isocyanides have been found to be valuable ligands for anchoring haloareneCr(CO)3 complexes by means of their substitution for a CO group. The supported fluorobenzene complex reacted with nitrogen-nucleophiles. (C) 2000 Elsevier Science Ltd.

Ceria-supported copper nanoparticles: A highly efficient and recyclable catalyst for N-arylation of indole

CuCeO2 catalytic nanomaterials have been synthesized by impregnation of ceria by copper acetate, followed by reduction and calcination under nitrogen. The components of these nanomaterials were characterized by means of XRD, XPS, N2

Hoveyda-Grubbs catalyst analogues bearing the derivatives of: N -phenylpyrrol in the carbene ligand-structure, stability, activity and unique ruthenium-phenyl interactions

We have synthesized a series of N-phenylpyrrole and N-phenylindole carbenes and used them as ruthenium-ligating moieties in the synthesis of Hoveyda-Grubbs catalyst derivatives. We show that most of these complexes are difficult to synthesize and unstable apart from the N-phenylpyrrole-2,6-diisopropylphenyl ruthenium complex and its perbrominated derivative. These two systems are almost completely inactive in ring-closing metathesis at room temperature and become active only at 80 °C. DFT, SAPT0 and DLPNO-CCSD(T) calculations suggest that the rarely occurring phenyl-ruthenium interactions are responsible for the very slow initiation of these precatalysts at low temperatures.

PEG3400-Cu2O-Cs2CO3: an efficient and recyclable microwave-enhanced catalytic system for ligand-free Ullmann arylation of indole and benzimidazole

A mild, simple and efficient microwave-enhanced copper-catalyzed protocol for N-arylation using high molecular weight poly(ethylene glycol) (PEG3400) as a solvent is reported. Indole and benzimidazole have been N-arylated in the presence of cup

Chemical synthesis, spectroscopic studies, chemical reactivity properties and bioactivity scores of an azepin-based molecule

Azepines derived molecules are of great interest because of their multi-drug like properties and thus advantageous in biomedical field. Herein, a novel route is described for the synthesis of an azepine-based molecule, 10,11-Dibromo-10,11-dihydro- 5H-dibenzo[b,f]azepine-5-carbonyl chloride (DACC) by using dibutyltin dilaurate (DBTDL) as catalyst. The structure of DACC was elucidated by using FT-IR, NMR, and mass spectroscopic techniques. Several density functionals were considered for the study of the molecular properties of the synthesized compound. The global and local reactivity descriptors were estimated by using Conceptual Density Functional Theory (CDFT). The active sites suitable for the nucleophilic and electrophilic attacks were selected by linking them with the Fukui indices, Parr functions and condensed Dual Descriptor Δf(r). Finally, the bioactivity scores for the studied molecule were predicted through different methodologies.

Double Ligands Enabled Ruthenium Catalyzed ortho-C?H Arylation of Dialkyl Biarylphosphines: Straight and Economic Synthesis of Highly Steric and Electron-Rich Aryl-Substituted Buchwald-Type Phosphines

A double-ligands enabled ruthenium catalyzed C(sp2)?H arylation of dialkyl phosphines is described, which provides a straight access to aryl-substituted dialkyl phosphine ligands. The combination of 1,3-diketone and amino acid ligands is essential for this transformation. An important six-membered cycloruthenium intermediate was successfully isolated and characterized by X-ray diffraction. Mechanistic studies showed that the 1,3-diketone promoted the process of oxidative addition of cycloruthenium intermediate. Some of modified CyJohnPhos ligands exhibited highly catalytic activity in palladium catalyzed C?N bond formation. (Figure presented.).

Cu(i) based catalysts derived from bidentate ligands and studies on the effect of substituents for: N -arylation of benzimidazoles and indoles

A family of Cu(i) complexes [Cu(L1-4)(Cl)(PPh3)] (C1-C4) were synthesized from bidentate ligands L1-L4 (where L1 = (E)-2-(2-benzylidene-1-phenylhydrazinyl)pyridine, L2 = (E)-N,N-dimethyl-4-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)aniline, L3 = (E)-2-(2

Electrospun copper oxide nanoparticles as an efficient heterogeneous catalyst for N-arylation of indole

The N-arylation of indoles with a variety of aryl bromides is reported using copper oxide nanoparticles as a heterogeneous catalyst. These copper oxide nanoparticles, which were produced in a novel, facile, and scalable fashion via an electrospinning tech