1600535-91-8Relevant academic research and scientific papers
Niacin as a Potent Organocatalyst towards the Synthesis of Quinazolines Using Nitriles as C–N Source
Gujjarappa, Raghuram,Vodnala, Nagaraju,Reddy, Velma Ganga,Malakar, Chandi C.
, p. 803 - 814 (2020)
An efficient and cost-effective Vitamin-B3-catalyzed protocol towards the synthesis of diversely substituted quinazolines is illustrated using 2-aminobenzylamines and nitriles as substrates. An organocatalytic transformation has been investigat
Quinazoline synthesis method in water
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Paragraph 0115; 0117; 0118, (2018/07/30)
The invention discloses a quinazoline synthesis method in water. The method comprises the steps that aldehyde, aminobenzylamine, a water-soluble complex catalyzer (an iridium or ruthenium complex catalyzer), solvent water and a reaction mixture are added in a container for several hours of reaction and cooled to the indoor temperature, rotary evaporation is carried out for removing a solvent, andcolumn separation is carried out to obtain a target compound. Compared with the reported documents, the method uses the water-soluble iridium or ruthenium complex catalyzer, the reaction only needs heating in the water and releases environmentally friendly hydrogen, an oxidizing agent or a hydrogen acceptor is not needed, and high economy and friendly environment of atoms are showed; therefore, the reaction conforms to the green chemistry requirements and has wide development prospects.
Copper-catalyzed domino reaction between 1-(2-halophenyl)methanamines and amidines or imidates for the synthesis of 2-substituted quinazolines
Omar, Mohamed A.,Conrad, Jürgen,Beifuss, Uwe
, p. 3061 - 3072 (2014/04/17)
The CuI-catalyzed domino reaction between 1-(2-bromophenyl)methanamines and amidines using K3PO4 as the base, pivalic acid as the additive, and aerial oxygen as the oxidant gives access to substituted quinazolines in a single step wi
