865718-75-8

Basic information

• Product Name: 2-BROMO-4-METHYLBENZYLAMINE
• Synonyms: 2-BROMO-4-METHYLBENZYLAMINE
• CAS NO: 865718-75-8
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.08
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 865718-75-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMO-4-METHYLBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-METHYLBENZYLAMINE(865718-75-8)
• EPA Substance Registry System: 2-BROMO-4-METHYLBENZYLAMINE(865718-75-8)

Safety Data

• Hazardous Substances Data: 865718-75-8(Hazardous Substances Data)

Upstream product

• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 42872-73-1 4-methyl-2-bromobenzonitrile 

Downstream Products

• 1600535-91-8 7-methyl-2-(4-chlorophenyl)quinazoline 
• 1600535-90-7 7-methyl-2-(4-methylphenyl)quinazoline 
• 1600535-89-4 7-methyl-2-phenylquinazoline 

Relevant articles and documents

Palladium-Catalyzed α-Arylation of Silylenol Ethers in the Synthesis of Isoquinolines and Phenanthridines

A diverse array of isoquinolines and phenanthridines have been accessed by developing a two-step, one-pot method constituting regioselective palladium-catalyzed Kuwajima-Urabe α-arylation of silylenol ethers and acid-mediated deprotection, annulation, and aromatization. Structural diversity in the silylenol ethers leads to three different classes of isoquinolines and phenanthridines from which related natural products can be derived. The synthetic utility of this method by the quick assembly of the natural product trispheridine is also demonstrated.

ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY

The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy

The synthesis of a unique isoindoline- and tetrahydroisoquinoline (THIQ)-containing tricyclic sultam library, utilizing a Heck-aza-Michael (HaM) strategy is reported. Both isoindoline and THIQ rings are installed through a Heck reaction on a vinylsulfonamide, followed by one-pot deprotection and intramolecular aza-Michael reaction. Subsequent cyclization with either paraformaldehyde condensation or 1,1′-carbonyldiimidazole coupling generates a variety of tricyclic sultams. Overall, a 160-member library of these sultams, together with their isoindolines/THIQ and secondary sulfonamides precursors, were constructed using this strategy.