160056-41-7

Upstream product

• 4712-55-4 diphenyl hydrogen phosphite 
• 81246-80-2 5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl uridine 

Downstream Products

• 120401-09-4 C₃₆H₄₄PO₁₀N₂Si^(1-)*C₆H₁₆N⁽¹⁺⁾ 
• 911848-49-2 SiC₆H₁₄PO₃HC(C₆H₅)3C₂H₃O₂C₉H₁₂N₂O₅C₂H₄ 
• 1231149-96-4 C₃₉H₅₃N₂O₉PSSi₂ 
• 1231149-96-4 C₃₉H₅₃N₂O₉PSSi₂ 
• 1231149-97-5 C₄₅H₅₇N₂O₁₀PSi₂ 
• 1231149-97-5 C₄₅H₅₇N₂O₁₀PSi₂ 

Relevant academic research and scientific papers

Studies on aryl H-phosphonates. I. An efficient method for the preparation of deoxyribo- and ribonucleoside 3'-H-phosphonate monoesters by transesterification of diphenyl H-phosphonate

A convenient method for the preparation of deoxyribonucleoside and ribonucleoside 3'-H-phosphonate monoesters via transesterification of diphenyl H-phosphonate with suitable protected nucleosides in pyridine is described.

Stereochemistry of internucleotide bond formation by the H-phosphonate method. 7. Stereoselective formation of ribonucleoside (RP)- and (SP)-3′-H-phosphonothioate monoesters

Ribonucleoside 3′-H-phosphonothioate monoesters exist in the form of (RP)- and (SP)-diastereomers. In order to obtain them in good yields and in high stereochemical purity, stereoselective strategies for their preparation were investigated. For the synthesis of the (RP)-isomer, a stereoselective sulfhydrolysis of an activated nucleoside H-phosphonate was developed, while the monoesters with an (SP)-configuration were prepared by asymmetric transformation of diastereomeric mixtures of nucleoside 3′-H-phosphonothioates using either a condensation with 9-fluorenemethanol, followed by β-elimination, or via pivaloylation-hydrolysis reaction sequence. A tentative assignment of the absolute configurations of the obtained diastereomers of 3′-H-phosphonothioate esters was carried out via a stereochemical correlation analysis.