160169-47-1

Basic information

• Product Name: [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester
• Synonyms: [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester;Ethyl N-Benzyloxycarbonyl-3-[(2R)-piperidinyl)]-2(E)-Propenoate
• CAS NO: 160169-47-1
• Molecular Formula: C₁₈H₂₃NO₄
• Molecular Weight: 317.38
• Product Categories: Chiral Reagents;Heterocycles;Chiral Reagents, Heterocycles
• Mol File: 160169-47-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 438.178°C at 760 mmHg
• Flash Point: 218.803°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: 00C
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• PKA: -3.07±0.40(Predicted)
• CAS DataBase Reference: [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(160169-47-1)
• EPA Substance Registry System: [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(160169-47-1)

Safety Data

• Hazardous Substances Data: 160169-47-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 160169-47-1 differently. You can refer to the following data:
1. Intermediate for the synthesis of Lentiginosine
2. Intermediate for the synthesis of Lentiginosine.

InChI:InChI=1/C18H23NO4/c1-2-22-17(20)12-11-16-10-6-7-13-19(16)18(21)23-14-15-8-4-3-5-9-15/h3-5,8-9,11-12,16H,2,6-7,10,13-14H2,1H3/b12-11+/t16-/m1/s1

Upstream product

• 1723-00-8 (R)-(+)-pipecolic acid 
• 154499-13-5 benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 501-53-1 benzyl chloroformate 
• 28697-07-6 (R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 
• 1068012-41-8 (R)-N-(benzyloxycarbonyl)-2-formylpiperidine 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 160096-51-5 (R)-2-((1R,2S)-2-Ethoxycarbonyl-1,2-dihydroxy-ethyl)-piperidine-1-carboxylic acid benzyl ester 
• 160169-49-3 (1R,2S,8aR)-1,2-dihydroxy-hexahydroindolizin-3(5H)-one 
• 125279-72-3 (1R,2R,8aR)-lentiginosine 

Relevant articles and documents

Stereoselective synthesis of (+)-and (-)-lentiginosine

Simple routes to (1R,2R,8aR)- and (1S,2S,8aS)-lentiginosine have been described, based on Sharpless asymmetric dihydroxylation, starting from (R)- and (S)-pipecolinic acids.