[R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester

Base Information

Chemical Name:[R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester
CAS No.:160169-47-1
Molecular Formula:C₁₈H₂₃NO₄
Molecular Weight:317.385
Hs Code.:
Mol file:160169-47-1.mol

Synonyms:1-Piperidinecarboxylicacid, 2-(3-ethoxy-3-oxo-1-propenyl)-, phenylmethyl ester, [R-(E)]- (9CI)

Suppliers and Price of [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EthylN-Benzyloxycarbonyl-3-[(2R)-piperidinyl)]-2(E)-propenoate
10mg
$ 145.00

Total 2 raw suppliers

Chemical Property of [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.577
Boiling Point:438.178°C at 760 mmHg
PKA:-3.07±0.40(Predicted)
Flash Point:218.803°C
PSA：55.84000
Density:1.183g/cm³
LogP:3.23490
Storage Temp.:00C
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

EthylN-Benzyloxycarbonyl-3-[(2R)-piperidinyl)]-2(E)-propenoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Intermediate for the synthesis of Lentiginosine Intermediate for the synthesis of Lentiginosine.

Technology Process of [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester

There total 5 articles about [R-(E)]-2-(3-Ethoxy-3-oxo-1-propenyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28697-07-6,28697-09-8,28697-11-2,71170-88-2
(R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid

: 160169-47-1
(R)-2-((E)-2-Ethoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: BH_3.SMe₂ / tetrahydrofuran / 10 h / 0 deg C to room temp.

2: pyridine.SO₃ / dimethylsulfoxide / 0.5 h / 0 deg C to room temp.

3: benzene / 10 h / Ambient temperature

With dimethylsulfide borane complex; sulfur trioxide pyridine complex; In tetrahydrofuran; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(00)78520-0

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 160169-47-1
(R)-2-((E)-2-Ethoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4N NaOH / 6 h / Ambient temperature

2: BH_3.SMe₂ / tetrahydrofuran / 10 h / 0 deg C to room temp.

3: pyridine.SO₃ / dimethylsulfoxide / 0.5 h / 0 deg C to room temp.

4: benzene / 10 h / Ambient temperature

With sodium hydroxide; dimethylsulfide borane complex; sulfur trioxide pyridine complex; In tetrahydrofuran; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(00)78520-0

Reference yield:

: 154499-13-5
benzyl (R)-2-(hydroxymethyl)piperidine-1-carboxylate

: 160169-47-1
(R)-2-((E)-2-Ethoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine.SO₃ / dimethylsulfoxide / 0.5 h / 0 deg C to room temp.

2: benzene / 10 h / Ambient temperature

With sulfur trioxide pyridine complex; In dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4039(00)78520-0