154499-13-5

Basic information

• Product Name: (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester
• Synonyms: (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester;(2R)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester;(R)-N-Benzyloxycarbonyl-2-piperidinemethanol;(R)-1-Cbz-2-(hydroxyMethyl)piperidine
• CAS NO: 154499-13-5
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Product Categories: Chiral Reagents;Heterocycles;Chiral Reagents, Heterocycles
• Mol File: 154499-13-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 396.374°C at 760 mmHg
• Flash Point: 193.52°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(154499-13-5)
• EPA Substance Registry System: (+)-2-(Hydroxymethyl)-1-piperidinecarboxylic Acid Phenylmethyl Ester(154499-13-5)

Safety Data

• Hazardous Substances Data: 154499-13-5(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

Intermediate for the preparation of 1-hydroxyalkyl-3-phenylthioureas as HDL- and Apo A-I-elevating agents

InChI:InChI=1/C14H19NO3/c16-10-13-8-4-5-9-15(13)14(17)18-11-12-6-2-1-3-7-12/h1-3,6-7,13,16H,4-5,8-11H2/t13-/m1/s1

Upstream product

• 123-20-6 vinyl n-butyrate 
• 105706-75-0 1-benzyloxycarbonyl-2-hydroxymethylpiperidine 
• 60369-19-9 (2R)-N-(benzyloxycarbonyl)-2-(methoxycarbonyl)piperidine 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 501-53-1 benzyl chloroformate 
• 28697-07-6 (R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 

Downstream Products

• 1389312-78-0 C₁₇H₂₃NO₆ 
• 1389312-79-1 C₁₇H₂₃NO₆ 
• 1192122-36-3 [(2R)-1-[(benzyloxy)carbonyl]piperidin-2-yl]methyl 4-methylpiperazine-1-carboxylate 
• 160096-51-5 (R)-2-((1R,2S)-2-Ethoxycarbonyl-1,2-dihydroxy-ethyl)-piperidine-1-carboxylic acid benzyl ester 
• 160169-47-1 (R)-2-((E)-2-Ethoxycarbonyl-vinyl)-piperidine-1-carboxylic acid benzyl ester 
• 160169-49-3 (1R,2S,8aR)-1,2-dihydroxy-hexahydroindolizin-3(5H)-one 
• 125279-72-3 (1R,2R,8aR)-lentiginosine 
• 539823-50-2 (R,E)-methyl 3-[1-(2-iodobenzoyl)piperidin-2-yl]acrylate 
• 539823-49-9 (R)-2-hydroxymethyl-1-(2-iodobenzoyl)piperidine 
• 3197-44-2 (2R)-piperidin-2-ylmethanol 
• 1068012-41-8 (R)-N-(benzyloxycarbonyl)-2-formylpiperidine 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

QUINAZOLINE DERIVATIVES

The invention provided a compound of formula (I) for use in the treatment of disease, in particular proliferative diseases such as cancer and for use in the preparation of medicaments for use in the treatment of proliferative diseases; the invention also

1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents

A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A-I-elevating agents. Derivatives 5h, 7j, 7n, and 7o were found to be as effective or superior to gemfibrozil (1).