16018-52-3

Basic information

• Product Name: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine
• Synonyms: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine
• CAS NO: 16018-52-3
• Molecular Formula: C₁₂H₁₃N₅O
• Molecular Weight: 243.26452
• Mol File: 16018-52-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 417.7°Cat760mmHg
• Flash Point: 206.4°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 3.47E-07mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine(16018-52-3)
• EPA Substance Registry System: N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine(16018-52-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 16018-52-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13N5O/c1-8-7-10(18)16-12(14-8)17-11(13)15-9-5-3-2-4-6-9/h2-7H,1H3,(H4,13,14,15,16,17,18)

Upstream product

• 62-53-3 aniline 
• 7152-19-4 2-cyano-amino-4-hydroxy-6-methyl-pyrimidine 
• 142-04-1 aniline hydrochloride 
• 141-97-9 ethyl acetoacetate 
• 102-02-3 1-phenylbiguanide 
• 7152-19-4 N-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyanamide 
• 674-82-8 4-methyleneoxetan-2-one 

Downstream Products

• 1381874-45-8 4,8-dimethyl-2-( phenylamino)-6H-pyrimido[1,2-a][1,3,5]-triazin-6-one 

Relevant articles and documents

Regioselective synthesis of pyrimido[1,2-a][1,3,5]triazin-6-ones via reaction of 1-(6-oxo-1,6-dihydropyrimidin-2-yl)guanidines with triethylorthoacetate: Observation of an unexpected rearrangement

A novel thermal rearrangement, involving pyrimidine ring opening and subsequent ring closure leading to recyclization of the system, was identified in the reaction of (6-oxo-1,6-dihydropyrimidin-2-yl)guanidines 3 (where NR 1R2 = NH2, NH alkyl, NH aralkyl, NHCH 2Ph(R)) with triethyl orthoacetate, affording 4-substituted-2-methyl- 6H-pyrimido[1,2-a][1,3,5]triazin-6-ones 6 and their ring opened products. However, no such rearrangement was observed with (6-oxo-1,6-dihydropyrimidin-2- yl)guanidines 3 bearing a tertiary amino or anilino substituent (i.e. where NR1R2 = N(CH3)2, indoline, morpholino, NHAr). As expected, 2-substituted-4-methyl-6H-pyrimido[1,2-a][1,3,5] triazin-6-ones 4 were obtained as the final products. Experimental structural determination and theoretical studies were carried out to get an understanding of the observed thermal rearrangement. In addition, an attempt to obtain similar pyrimido[1,2-a][1,3,5]triazin-6-ones using N,N-dimethylacetamide dimethyl acetal (DMA-DMA) as one carbon inserting synthon had furnished triazine ring annulated product 14 bearing N,N-dimethyl enamino substituent at position 4 as a result of further reaction with a second molecule of DMA-DMA.

Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists

A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed.

Reaction of biguanides and related compounds. VIII. The condensation of arylbiguanides and N amidino O alkylisoureas with diketene and ethyl acetoacetate

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