16018-83-0

Basic information

• Product Name: 1-(4-FLUOROPHENYL)BIGUANIDE HYDROCHLORIDE
• Synonyms: 1-(p-fluorophenyl)biguanidehydrochloride;1-(p-fluorophenyl)-biguanidmonohydrochloride;n-(4-fluorophenyl)-imidodicarbonimidicdiamidemonohydrochloride;BUTTPARK 24\02-83;1-(4-FLUOROPHENYL)BIGUANIDE HYDROCHLORIDE;1-(4-FLUOROPHENYL)BIGUANIDINE HYDROCHLORIDE;[[(4-FLUOROANILINO)(IMINO)METHYL]AMINO]METHANIMIDAMIDE HYDROCHLORIDE;N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE
• CAS NO: 16018-83-0
• Molecular Formula: C₈H₁₀FN₅*ClH
• Molecular Weight: 231.66
• Product Categories: Miscellaneous;Guanidines;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 16018-83-0.mol

Chemical Properties

• Melting Point: 250-254 °C(lit.)
• Boiling Point: 396.3°Cat760mmHg
• Flash Point: 193.5°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)BIGUANIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)BIGUANIDE HYDROCHLORIDE(16018-83-0)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)BIGUANIDE HYDROCHLORIDE(16018-83-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DU1850000
• Hazardous Substances Data: 16018-83-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
1-(4-Fluorophenyl)biguanide hydrochloride is used as an intermediate in the chemical synthesis of several biologically active substances. Its presence in the biguanide family and the addition of a fluorine atom contribute to its enhanced biological activity, making it a valuable component in the creation of various compounds.
Used in Pharmaceutical Research:
1-(4-Fluorophenyl)biguanide hydrochloride is used as a research compound in the development of new pharmaceuticals. Its antimalarial, antifungal, and antimicrobial properties, along with its water-solubility due to the hydrochloride salt form, make it a promising candidate for the treatment of various diseases and infections.
Used in Antimicrobial Applications:
1-(4-Fluorophenyl)biguanide hydrochloride is used as an antimicrobial agent for its ability to combat a range of microorganisms. Its biguanide nature and the presence of a fluorine atom enhance its effectiveness in inhibiting the growth of bacteria, fungi, and other pathogens, making it a potential candidate for use in antimicrobial products.
Used in Antimalarial Applications:
1-(4-Fluorophenyl)biguanide hydrochloride is used as an antimalarial agent, leveraging its biguanide properties to target and inhibit the growth of Plasmodium parasites responsible for malaria. The addition of a fluorine atom may further improve its efficacy in treating this disease.
Used in Antifungal Applications:
1-(4-Fluorophenyl)biguanide hydrochloride is used as an antifungal agent, where its biguanide structure and fluorine atom contribute to its ability to inhibit the growth of fungi. This makes it a potential candidate for use in antifungal medications and treatments.

InChI:InChI=1/C8H10FN5.ClH/c9-5-1-3-6(4-2-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 16018-82-9 1-carbamimidamido-N-(4-fluorophenyl)methanimidamide 

Relevant articles and documents

BIGUANIDE COMPOUNDS AND USE THEREOF

The present invention relates to a biguanide compound and uses thereof. More specifically, the present invention relates to: a biguanide derivative exhibiting excellent effects in inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a manufacturing method of the biguanide derivative; and a pharmaceutical composition containing the biguanide derivative as an active component.

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2

By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2.gdb.tools), which suggested lysophosphatidic acid acyltransferase β (LPAAT-β) as a possible target for this aminotriazine as well as several analogues identified by structure–activity relationship profiling. LPAAT-β inhibition (IC50 ≈15 nm) was confirmed in a biochemical assay and by its effects on cell proliferation in comparison with a known LPAAT-β inhibitor. These experiments illustrate the value of target-prediction tools to guide target identification for phenotypic screening hits and significantly expand the rather limited pharmacology of LPAAT-β inhibitors.

NOVEL CYCLIC GMP-AMP SYNTHASE (CGAS) INHIBITORS AND THEIR METHOD OF USE

Methods of treating diseases related to cGAS activation. Small molecule inhibitors of cGAS and pharmaceutical compositions and uses thereof in treating autoimmune diseases or inflammation.

BIGUANIDE COMPOUNDS AND USE THEREOF

The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for pre