160237-44-5

Basic information

• Product Name: C₄₃H₅₆O₁₂Si
• Synonyms: C₄₃H₅₆O₁₂Si
• CAS NO: 160237-44-5
• Molecular Weight: 792.996
• Mol File: 160237-44-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₄₃H₅₆O₁₂Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₅₆O₁₂Si(160237-44-5)
• EPA Substance Registry System: C₄₃H₅₆O₁₂Si(160237-44-5)

Safety Data

• Hazardous Substances Data: 160237-44-5(Hazardous Substances Data)

Upstream product

• 260249-48-7 C₆₁H₇₁NO₁₆Si 
• 260249-47-6 C₅₉H₆₇N₃O₁₄Si 
• 260249-46-5 C₅₉H₆₉NO₁₄Si 
• 260245-86-1 C₅₂H₆₂O₁₄Si 
• 994-30-9 triethylsilyl chloride 
• 32981-86-5 10-deacetylbaccatin III 
• 501-53-1 benzyl chloroformate 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 260249-52-3 C₅₉H₆₉NO₁₅Si 

Downstream Products

• 478161-74-9 C₄₉H₇₀O₁₂Si₂ 
• 478161-78-3 C₅₄H₇₇FN₂O₁₃Si 
• 478161-66-9 C₄₃H₅₆O₁₂Si 
• 478161-67-0 (1S,2S,3R,4S,5R,7R,8R,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-10-[(benzyloxycar bonyl)oxy]-5,20-epoxy-7-fluoro-1-hydroxy-9-oxo-13-[(triethylsilyl)oxy]tax-11-ene 
• 478161-77-2 C₃₈H₅₅FO₉Si 
• 478161-75-0 (1S,2S,3R,4S,5R,7R,8R,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-1,10-dihydroxy-5,20-epoxy-7-fluoro-9-oxo-13-[(triethylsilyl)oxy]tax-11-ene 
• 478161-76-1 (1S,2S,3R,4S,5R,7R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-7-fluoro-13-[(triethylsilyl)oxy]-1,9,10-trihydroxytax-11-ene 
• 184586-11-6 C₃₂H₄₁FO₉ 
• 1053256-32-8 C₃₉H₄₄O₁₃ 
• 848251-58-1 7-triethylsilyl-10-deacetyl-10-benzoyloxycarbonyl-13-acetylbaccatin III 
• 260245-86-1 C₅₂H₆₂O₁₄Si 

Relevant articles and documents

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

A series of novel taxane-based multidrug resistance (MDR) reversal agents (TRAs) has been designed and synthesized. Structure - activity relationship (SAR) study clearly indicates that modification of the C-7 position with hydrophobic arenecarbonylcinnamoyl groups brings about high potency against drug efflux mediated by P-glycoprotein (P-gp). Six TRAs exhibit ability to modulate a wide range of ATP-binding cassette (ABC) transporters, such as P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), which may serve as novel broad-spectrum modulators of ABC transporters.

A semisynthesis of paclitaxel via a 10-deacetylbaccatin III derivative bearing a β-keto ester appendage

A semisynthesis of paclitaxel has successfully been accomplished starting from a newly developed baccatin III derivative bearing a β-keto ester appendage on C-13.