478161-76-1

Upstream product

• 478161-74-9 C₄₉H₇₀O₁₂Si₂ 
• 478161-66-9 C₄₃H₅₆O₁₂Si 
• 478161-67-0 (1S,2S,3R,4S,5R,7R,8R,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-10-[(benzyloxycar bonyl)oxy]-5,20-epoxy-7-fluoro-1-hydroxy-9-oxo-13-[(triethylsilyl)oxy]tax-11-ene 
• 160237-44-5 C₄₃H₅₆O₁₂Si 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 994-30-9 triethylsilyl chloride 
• 478161-75-0 (1S,2S,3R,4S,5R,7R,8R,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-1,10-dihydroxy-5,20-epoxy-7-fluoro-9-oxo-13-[(triethylsilyl)oxy]tax-11-ene 

Downstream Products

• 478161-78-3 C₅₄H₇₇FN₂O₁₃Si 
• 184586-11-6 C₃₂H₄₁FO₉ 
• 478161-77-2 C₃₈H₅₅FO₉Si 

Relevant academic research and scientific papers

TAXANE COMPOUND WITH AZETIDINE RING STRUCTURE

A compound represented by the general formula (1) [X1 and X2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, R1 represents a phenyl group, R2 represents an alkyl group, an alkenyl group, or

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

To investigate structure-activity relationships of the 9,10-acetal-9β-dihydro taxoids, we modified the 7-hydroxyl groups of the 9,10-acetonide-3′-(4-pyridyl) analogue to deoxy, methoxy, α-F, and 7β,8β-methano group. As a result of this study, we found that the 7-deoxy analogue was the strongest among these analogues. In addition, we found that the 7-deoxy-3′-(4-pyridyl) and 7-deoxy-3′-(2-pyridyl) analogues showed stronger activity against cell lines expressing P-glycoprotein than the corresponding 3′-phenyl analogue.