160237-99-0

Basic information

• Product Name: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone
• Synonyms: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone
• CAS NO: 160237-99-0
• Molecular Weight: 313.353
• Mol File: 160237-99-0.mol

Chemical Properties

• CAS DataBase Reference: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone(160237-99-0)
• EPA Substance Registry System: (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(hydroxymethyl)-2-azetidinone(160237-99-0)

Safety Data

• Hazardous Substances Data: 160237-99-0(Hazardous Substances Data)

Upstream product

• 927-77-5 n-propylmagnesium bromide 
• 160334-80-5 (-)-(3R,4S)-trans-3-benzyloxy-4-formyl-1-(p-methoxyphenyl)-2-azetidinone 
• 141268-44-2 1-(4-methoxyphenyl)-3-(phenylmethoxy)-4-(1,4-dioxaspiro<4.5>dec-2-yl)azetidin-2-one 
• 141781-23-9 [(S)-1-(1,4-Dioxa-spiro[4.5]dec-2-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine 
• 139007-45-7 S-(2-Pyridyl) 2-(phenylmethoxy)ethanethioate 
• 149818-33-7 (+)-(3R,4S)-cis-3-benzyloxy-4-[(S)-1',2'-dihydroxyethyl]-1-(p-methoxyphenyl)-2-azetidinone 
• 160237-98-9 (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-vinyl-2-azetidinone 
• 115857-84-6 (3R,4S)-3-(Benzyloxy)-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>-1-(4-methoxyphenyl)azetidin-2-one 
• 148968-08-5 (+)-(3R,4R)-1-(p-anisyl)-3-benzyloxy-4-formyl-2-azetidinone 

Downstream Products

• 160238-00-6 (3R,4S)-1-(4-methoxyphenyl)-3-(benzyloxy)-4-(bromomethyl)-2-azetidinone 
• 351074-49-2 (+)-(3R,4S)-1-(4-methoxyphenyl)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 614733-15-2 (+)-(3R,4S)-1-(p-anisyl)-4-(methanesulfonyloxymethyl)-3-benzyloxy-2-azetidinone 
• 954109-50-3 (3R,4S)-3-(benzyloxy)-4-(hydroxymethyl)azetidin-2-one 
• 954109-51-4 (3R,4S)-3-(benzyloxy)-1-(tert-butoxycarbonyl)-4-[(tert-butoxycarbonyloxy)methyl]azetidin-2-one 
• 954109-53-6 (3R,4S)-3-(benzyloxy)-4-[(tert-butyldimethylsilyloxy)methyl]azetidin-2-one 
• 954109-54-7 (3R,4S)-3-(benzyloxy)-1-(tert-butoxycarbonyl)-4-[(tert-butyldimethylsilyloxy)methyl]azetidin-2-one 
• 954109-55-8 (2S,3R)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-1-(tert-butyldimethylsilyloxy)octadecan-4-one 
• 165672-52-6 (-)-(5S,6S)-1-benzyl-5-(benzyloxy)6-methyl-hexahydro-2-pyridinone 
• 614733-12-9 (-)-(3R,4S)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 351074-58-3 (+)-(5S,6S)-5-benzyloxy-6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-1,2,5,6-tetrahydro-2-pyridinone 
• 351074-54-9 (2R,3S)-2-benzyloxy-3-[(tert-butyloxycarbonyl)amino]-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)butanal 
• 351074-50-5 (+)-(3R,4S)-1-(tert-butyloxycarbonyl)-3-benzyloxy-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-azetidinone 
• 351074-52-7 (-)-(2R,3S)-2-benzyloxy-3-[(tert-butyloxycarbonyl)amino]-4-({[tert-butyl(diphenyl)silyl]oxy}methyl)butan-1-ol 

Relevant articles and documents

4-Formylazetidin-2-one as a useful building block for the formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine

Stereoselective formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(25,35)-sphingosine is described starting from an enantiopure formyl-substituted β-lactam. Grignard reaction of the N-Boc-protected- β-lactam carbonyl group, followed by furthe

Facile conversion of 2-azetidinones to 2-piperidones: Application to a formal synthesis of Prosopis and Cassia alkaloids

Nonracemic 5,6-disubstituted 2-piperidones were prepared from readily accessible 3,4-disubstituted-2-azetidinones having pre-installed substituents by reductive ring opening of 2-azetidinones followed by stereoselective installation of Z-α,β-unsaturated ester and lactam formation. For the synthetic application to the naturally occurring piperidine alkaloids, such as Prosopis and Cassia alkaloids, 5-hydroxy-2-piperidones (+)-13 and (-)-24 were prepared from 2-azetidinones (-)-6b and (+)-18 via two-carbon ring homologation.

Facile transformation of 3,4-disubstituted 2-azetidinones to chiral 5,6-dihydro-2-pyridones

Chiral 5,6-disubstituted-5,6-dihydro-2(1H)-pyridones were prepared efficiently from readily accessible 3,4-disubstituted-2-azetidinones having preadjusted substituents and stereochemistry through the reductive ring opening of 2-azetidinones followed by Z-selective installation of acetate moiety and re-cyclization to 2-pyridones.

Synthesis and Biological Evaluation of C-3'-Modified Analogs of 9(R)-Dihydrotaxol

Taxol (1) is considered a most exciting new drug in cancer chemotherapy.The promising antitumor activity of 9(R)-dihydrotaxol (3) encouraged us to further explore the structure-activity relationship of this new member of the taxane family.Studies indicate