160238-89-1Relevant academic research and scientific papers
Monodentate Transient Directing Group-Assisted Palladium-Catalyzed Direct ortho-C-H Iodination of Benzaldehydes for Total Synthesis of Hernandial
Chen, Xuerong,La, Ming,Liu, Dandan,Zhang, Fang-Lin,Zhou, Yirong
supporting information, p. 9184 - 9188 (2021/11/30)
The first palladium-catalyzed direct o-C-H iodination of benzaldehydes was successfully developed with the assistance of commercially available 2,5-bis(trifluoromethyl)aniline as the optimal monodentate transient directing group (MonoTDG). Moderate to exc
1,4-Pentenyne as a five-carbon synthon for efficient and selective syntheses of natural products containing 2,4-dimethyl-1-penten-1,5-ylidene and related moieties by means of Zr-catalyzed carboalumination of alkynes and alkenes
Zhu, Gangguo,Negishi, Ei-Ichi
, p. 311 - 318 (2008/09/18)
Two highly efficient protocols for enantioselective synthesis of 2,4-dimethyl-1-penten-1,5-ylidene derivatives involve the combined use of the Zr-catalyzed methylalumination of alkynes (ZMA) and the Zr-catalyzed asymmetric carboalumination of alkenes (ZAC
Iodination of Methylated Anisoles: Unusual Aryl Methyl Replacement and Oxidations
Panetta, Charles A.,Fang, Zheng,Mattern, Daniell L.
, p. 7953 - 7958 (2007/10/03)
The treatment of methylated anisoles with iodine, periodic acid, sulfuric acid, and aqueous acetic acid has resulted in iododemethylations and/or aryl methyl oxidations in addition to the expected mono- and diiodinations of the aromatic ring.Four dimethylanisoles and o-methylanisole were treated under identical conditions.Iododemethylations were observed in three of the four dimethylanisoles and aryl methyl oxidations to benzaldehydes occured with o-methylanisole and two of the dimethylanisoles.No precedence could be found for either of these reactions under the experimental conditions employed.Several possible mechanisms are discussed for these transformations.Some experimental evidence suggests that methyl oxidation to a benzaldehyde could be a prerequisite for an iododemethylation via an iodonium ion-assisted reverse Gatterman-Koch reaction; single-electron-transfer or classical electrophilic mechanisms are also consistent with the iododemethylations.
FACILE CONSTRUCTION OF MEDIUM-SIZED CARBOCYCLES, TOTAL SYNTHESIS OF (+/-)-PARVIFOLINE
Grimm, Erich L.,Levac, Sylvain,Coutu, Michel L.
, p. 501 - 502 (2007/10/02)
A new synthetic approach to medium-sized rings has been accomplished via intramolecular cyclization of a sulfone-stabilized carbanion.This strategy was applied to the total synthesis of (+/-)-parvifoline.
