Synthesis and structure-activity relationships of nonaromatic taxoids: Effects of alkyl and alkenyl ester groups on cytotoxicity

Article abstract of DOI:10.1021/jm9606711

Several new nonaromatic taxoids are synthesized by means of the β- lactam synthon method. These include taxoids modified with 3-methylbut-2- enoate, 3-methylbutanoate, and cyclohexanecarboxylate groups in place of the benzoate at the C-2 position. In addi