16024-13-8Relevant academic research and scientific papers
Synthesis and in vitro evaluation of leishmanicidal activity of 7-hydroxy-4-phenylcoumarin derivatives
Rosa, Isael A.,de Almeida, Letícia,Alves, Karina F.,Marques, Marcos J.,Fregnan, Ant?nio M.,Silva, Claudinei A.,Giacoppo, Juliana O. S.,Ramalho, Teodorico C.,Carvalho, Diogo T.,dos Santos, Marcelo H.
, p. 131 - 139 (2017)
Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against promastigote and amastigote forms of Leishmania amazonensis, as well their toxicity in murine macroph
Synthesis and anti-proliferative activity of novel oxepin-annulated coumarins
Prateeptongkum, Saisuree,Mahavorasirikul, Wiratchanee,Duangdee, Nongnaphat
, p. 73 - 85 (2018/10/26)
A series of fused dihydrooxepino[h]- and dihydrooxepino[g]coumarins (7 and 8) were synthesized through allylation, Claisen rearrangement, allylation and ring-closing metathesis (RCM), respectively. All the synthesized compounds were characterized by appropriate spectral analysis. The anti-proliferative activities of compound 5a-c, 6a, 6c, 7a-c and 8a-c were evaluated against human colon cancer (Caco-2), liver cancer (HepG2) and breast cancer (SKBR-3) cell lines using tamoxifen (TAM) as the positive control. Compound 7b showed significant anti-proliferative activity against resistant Caco-2 and SKBR-3 cell lines on comparison with all other coumarin derivatives. Interestingly, compound 8b was more potent than TAM against sensitive HepG2 cell line.
Benzopyranone and quinolone inhibitors of ras farnesyl transferase
-
, (2008/06/13)
The present invention provides ras farnesyl transferase inhibiting compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
