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CAS

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160252-31-3

5-Acetyl-2-chloropyrazine is an organic compound characterized by its yellow solid appearance. It is a derivative of pyrazine, a heterocyclic compound with a six-membered nitrogen-containing ring. The specific structure of 5-Acetyl-2-chloropyrazine features an acetyl group at the 5th position and a chlorine atom at the 2nd position, which contributes to its unique chemical properties and potential applications.

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  • 160252-31-3 Structure

  • Basic information

    1. Product Name: 5-Acetyl-2-chloropyrazine
    2. Synonyms: 1-(5-chloropyrazin-2-yl)ethanone;1-(5-chloropyrazin-2-yl)ethan-1-one;1-(5-Chloro-2-pyrazinyl)ethanone;1-(5-Chloropyrazinyl)ethanone;2-Chloro-5-acetylpyperazine;5-Acetyl-2-chloropyrazine
    3. CAS NO:160252-31-3
    4. Molecular Formula: C6H5ClN2O
    5. Molecular Weight: 156.5697
    6. EINECS: N/A
    7. Product Categories: Aromatics;Heterocycles;Inhibitors
    8. Mol File: 160252-31-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 259.52 °C at 760 mmHg
    3. Flash Point: 110.754 °C
    4. Appearance: /
    5. Density: 1.312 g/cm3
    6. Vapor Pressure: 0.013mmHg at 25°C
    7. Refractive Index: 1.538
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: Chloroform (Slightly), Methanol (Slightly)
    10. PKA: -3.33±0.10(Predicted)
    11. CAS DataBase Reference: 5-Acetyl-2-chloropyrazine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 5-Acetyl-2-chloropyrazine(160252-31-3)
    13. EPA Substance Registry System: 5-Acetyl-2-chloropyrazine(160252-31-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 160252-31-3(Hazardous Substances Data)

160252-31-3 Usage

Uses

Used in Pharmaceutical Industry:
5-Acetyl-2-chloropyrazine is used as a key intermediate in the synthesis of 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidines. These compounds are of significant interest due to their adenosine kinase inhibitory properties, which can be leveraged in the development of therapeutic agents for various diseases and conditions. The inhibition of adenosine kinase has been associated with potential therapeutic benefits in cancer treatment, neurodegenerative disorders, and other pathologies.

Check Digit Verification of cas no

The CAS Registry Mumber 160252-31-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,0,2,5 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 160252-31:
(8*1)+(7*6)+(6*0)+(5*2)+(4*5)+(3*2)+(2*3)+(1*1)=93
93 % 10 = 3
So 160252-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClN2O/c1-4(10)5-2-9-6(7)3-8-5/h2-3H,1H3

160252-31-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(5-Chloropyrazin-2-yl)ethanone

1.2 Other means of identification

Product number -
Other names 1-(5-chloropyrazin-2-yl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:160252-31-3 SDS

160252-31-3Relevant articles and documents

ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS

-

, (2018/02/27)

The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.

5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d] pyrimidin-4-ylamine: Structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors

Matulenko, Mark A.,Lee, Chih-Hung,Jiang, Meiqun,Frey, Robin R.,Cowart, Marlon D.,Bayburt, Erol K.,DiDomenico Jr., Stanley,Gfesser, Gregory A.,Gomtsyan, Arthur,Guo, Zhu Zheng,McKie, Jeffery A.,Stewart, Andrew O.,Yu, Haixia,Kohlhaas, Kathy L.,Alexander, Karen M.,McGaraughty, Steve,Wismer, Carol T.,Mikusa, Joseph,Marsh, Kennan C.,Snyder, Ronald D.,Diehl, Marilyn S.,Kowaluk, Elizabeth A.,Jarvis, Michael F.,Bhagwat, Shripad S.

, p. 3705 - 3720 (2007/10/03)

4-Amino-5,7-disubstituted pyridopyrimidines are potent, non-nucleoside inhibitors of adenosine kinase (AK). We recently identified a potent, orally efficacious analog, 4 containing a 7-pyridylmorpholine substituted ring system as the key structural element of this template. In this report, we disclose the pharmacologic effects of five- and six-membered heterocyclic ring replacements for the pyridine ring in 4. These replacements were found to have interesting effects on in vivo efficacy and genotoxicity as well as in vitro potency. We discovered that the nitrogen in the heterocyclic ring at C(7) is important for the modulation of mutagenic side effects (Ames assay).

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