160313-82-6

Basic information

• Product Name: N-trimethylsilyl-4-fluorobenzaldimine
• Synonyms: N-trimethylsilyl-4-fluorobenzaldimine
• CAS NO: 160313-82-6
• Molecular Weight: 195.312
• Mol File: 160313-82-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N-trimethylsilyl-4-fluorobenzaldimine(CAS DataBase Reference)
• NIST Chemistry Reference: N-trimethylsilyl-4-fluorobenzaldimine(160313-82-6)
• EPA Substance Registry System: N-trimethylsilyl-4-fluorobenzaldimine(160313-82-6)

Safety Data

• Hazardous Substances Data: 160313-82-6(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 4039-32-1 lithium hexamethyldisilazane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 199604-18-7 N-methoxycarbonyl-4-fluorobenzaldimine 
• 133235-84-4 1-(4-fluorophenyl)-2-phenylethan-1-amine 
• 1351557-61-3 C₁₆H₁₆FN 
• 1351557-63-5 4-amino-4-(4-fluorophenyl)-1-(2-methyl-1,3-dithian-2-yl)-2-methylenebutan-1-ol 
• 1351557-64-6 6-(4-fluorophenyl)-2,4-dimethylpyridin-3-ol 
• 1443050-09-6 tert-butyl ((S)-1-(((R)-(4-fluorophenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1443050-10-9 tert-butyl ((S)-1-(((S)-(4-fluorophenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1443050-11-0 (R)-((4-fluorophenyl)(pivalamido)methyl)boronic acid 
• 1443049-94-2 (R)-N-((4-fluorophenyl)(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)pivalamide 

Relevant articles and documents

1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery

The 2-substituted piperidine core is found in drugs (18 FDA-approved drugs), however, their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic analogues for 2-substituted piperidines and a demonstration of their validation in drug discovery.

Chiral phosphoric acid catalyzed enantioselective [4 + 2] cycloaddition reaction of α-fluorostyrenes with imines

An enantioselective [4 + 2] cycloaddition reaction of α-fluorostyrenes with N-benzoyl imines was demonstrated using a chiral phosphoric acid catalyst. Cycloaddition products having fluorine functionality were formed in high yields with excellent diastereo

Three-component coupling sequence for the regiospecific synthesis of substituted pyridines

A de novo synthesis of substituted pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an α,β- unsaturated carbonyl followed by metallacycle-mediated union of the resulting allylic alcohol with preformed trimethylsilane-imines (generated in situ by the low-temperature reaction of lithium hexamethyldisilazide with an aldehyde) and Ag(I)- or Hg(II)-mediated ring closure. The process is useful for the convergent assembly of di- through penta-substituted pyridines with complete regiochemical control.