16034-14-3

Upstream product

• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 100-51-6 benzyl alcohol 
• 626-19-7 Isophthalaldehyde 
• 100-39-0 benzyl bromide 
• 1459-93-4 dimethyl Isophthalate 

Downstream Products

• 121-91-5 isophthalic acid 
• 620-47-3 1-methyl-3-(phenylmethyl)-benzene 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 713-36-0 2-benzyltoluene 
• 113266-88-9 iso-phthalic acid monobenzyl ester 

Relevant academic research and scientific papers

Programming of microwave-assisted synthesis of new isophthalate derivatives using ZrOCl2 as a catalyst under solvent-free condition by experimental design

In this investigation, isophthalate derivatives were prepared by the reaction of isophthaloyl dichloride with various alcohol derivatives using ZrOCl2 as an efficient, green and a heterogeneous catalyst under microwave irradiation and solvent- free condition. Optimization of the reaction condition was studied by the response surface method (Box Behnken Design (BBD)) with three replicates at a central point for developing a second order model. Predicting response values using the obtained model were in a good accordance with the experimental results. Clean reaction, easy workup procedure, the reusability of the catalyst, short reaction times and high yields were some advantages of this work.

Electrogenerated N-heterocyclic carbene in ionic liquid: An insight into the mechanism of the oxidative esterification of aromatic aldehydes

An N-heterocyclic carbene (NHC), generated by cathodic reduction of BMIm BF4, mediates the oxidative esterification of aromatic aldehydes with organic bromides in the corresponding ionic liquid as solvent. The product recovery by simple extractive work-up with diethyl ether allowed the ionic liquid to be recycled up to 9 times for subsequent electrolyses, with no significant loss in the product yield. The isolation of an intermediate, whose structure was confirmed by synthesis and transformation into the ester, provided the key for a mechanistic insight into the reaction.

Isophthalic acid derivatives as matrix metalloproteinase inhibitors

Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, C2-C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.

NOVEL DISTANNOXANE-CATALYZED TRANSESTERIFICATION AND A NEW ENTRY TO α,β-UNSATURATED CARBOXYLIC ACIDS

Novel distannoxane-catalyzed transesterification reaction has been developed which affords various types of esters under very mild conditions.The reaction was applied to the stereo- and regioselective synthesis of trisubstituted α,β-unsaturated carboxylic acids.