1604039-54-4

Basic information

• Product Name: trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane
• Synonyms: trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane
• CAS NO: 1604039-54-4
• Molecular Weight: 182.338
• Mol File: 1604039-54-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 209.0±29.0 °C(Predicted)
• Density: 0.90±0.1 g/cm3(Predicted)
• CAS DataBase Reference: trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane(CAS DataBase Reference)
• NIST Chemistry Reference: trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane(1604039-54-4)
• EPA Substance Registry System: trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane(1604039-54-4)

Safety Data

• Hazardous Substances Data: 1604039-54-4(Hazardous Substances Data)

Upstream product

• 25637-18-7 4-iodotetrahydropyran 
• 1066-54-2 trimethylsilylacetylene 
• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 
• 75-77-4 chloro-trimethyl-silane 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 101765-10-0 tetrahydro-4-(methoxymethylene)-2H-pyran 
• 61210-52-4 (trimethylsilyl)ethynylmagnesium bromide 

Relevant articles and documents

7- OR 8-HYDROXY-ISOQUINOLINE AND 7- OR 8-HYDROXY-QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD)

7- or 8-hydroxy-isoquinoline and 7- or 8-hydroxy-quinoline derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).

Synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine

The invention relates to the technical field of organic synthesis. For solving the problems that a conventional synthesis method of 4-ethynyl-tetrahydropyran and 4-ethynyl piperidine is complex in operation, high in cost and unsuitable for industrial production in the prior art, the invention provides a synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine, wherein the synthesis method comprises the following steps: carrying out Wittig reaction on carbonyl of a compound represented by the formula (I) and phosphorus ylide salt under the action of a strong alkali to generate a compound represented by the formula (II), wherein the reaction temperature is 0-50 DEG C; (2) hydrolyzing the compound represented by the formula (II) to generate a compound represented by the formula (III), wherein the reaction temperature is 20-60 DEG C; (3) carrying out a Corey-Fuchs reaction on the compound represented by the formula (III) to obtain a compound represented by the formula (IV), wherein the reaction temperature is -20 to 40 DEG C; and (4) carrying out a reaction of the compound represented by the formula (IV) with a strong alkali, and carrying out a reaction with a silica reagent to generate a compound represented by the formula (V), wherein the reaction temperature is -70 to 20 DEG C. The method has the advantages of simple and accessible raw materials, low cost, simple synthesis steps and high yield, and is suitable for laboratory small-scale preparation and industrial production.