160412-57-7Relevant academic research and scientific papers
Synthesis and evaluation of N-acetyl-l-tyrosine based compounds as PPARα selective activators
Kumar, Rakesh,Ramachandran, Uma,Raichur, Suryaprakash,Chakrabarti, Ranjan,Jain, Rahul
, p. 503 - 510 (2008/02/09)
The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-l-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARα transactivation as compared to PPARγ. Molecular docking analysis was carried out to study their important interactions with the active site of PPARα.
Synthesis of Z-1,1-Dichloro-2--2-(4-hydroxyphenyl)-3-phenyl Cyclopropane and Z-1,1-Dichloro-2--2-(4-chlorophenyl)-3-phenyl Cyclopropane
Singh, Satendra,Magarian, Robert A.
, p. 1821 - 1824 (2007/10/02)
The synthesis of title compounds is described.The key steps in the synthesis are the preparation of the pure Z-ethene, the stereospecific addition of dichlorocarbene, amino-dehalogenation and deprotection of the phenol.Heptafluorotolyl protecting group is
