16053-68-2Relevant academic research and scientific papers
Synthesis and cellular studies of PPIX-homing peptide conjugates
Sibrian-Vazquez, Martha,Hu, Xiaoke,Jensen, Timothy J.,Vicente, M. Gra?a H.
scheme or table, p. 603 - 615 (2012/09/08)
Five amphiphilic protoporphyrin IX-peptide conjugates bearing the sequences ATWLPPR, AAhexPQRRSARLSA and cERGDPhe conjugated via the propionic side chains, were synthesized and evaluated in vitro using two cell lines: human carcinoma HEp2 and human leukem
Partial Syntheses of the Isomerically Pure Magnesium(II) Protoporphyrin IX Monomethyl Esters, and Their Identification
Shiau, Fuu-Yau,Whyte, Barry J.,Castelfranco, Paul A.,Smith, Kevin M.
, p. 1781 - 1785 (2007/10/02)
Treatment of 2,4-diacetyldeuteroporphyrin IX with oxalyl dichloride and t-butyl alcohol gives mainly the two isomeric mono-t-butyl esters, 10 and 11, which can be separated by thick-layer chromatography on silica gel.These monoesters can be individually transformed, via a sequence of steps, into the corresponding isomerically pure protoporphyrin IX monomethyl esters, 5 and 6, one being the magnesium(II)-free derivative of the key intermediate in the biosynthetic pathway to chlorophylls and bacteriochlorophylls.The isomerically pure monomethyl esters 5 and 6 were magnesiated and the resulting magnesium(II) protoporphyrin IX monomethyl esters 2 and 4, respectively, were challenged with a suspension of isolated developing chloroplasts in the presence and absence of added S-adenosylmethionine.The isomerically pure isomer which was converted into magnesium(II) 2,4-divinylpheoporphyrin a5 3 in the absence of SAM cofactor was identified as the physiologically significant 6-methyl ester 2.
