1605320-53-3Relevant academic research and scientific papers
A new tandem synthesis of bis(β,β′-dialkoxy carbonyl) compounds by oxidative cleavage of aziridines under metal-free conditions
Samanta, Satyajit,Santra, Sougata,Chatterjee, Rana,Majee, Adinath
, p. 551 - 556 (2020/01/30)
An efficient and new approach has been developed to synthesize bis(β,β′-dialkoxy carbonyl) derivatives through the reaction between N-tosylaziridines and malonate esters under ambient air using tBuOK in DMSO solvent. A plausible reaction pathway has been predicted. Control experiments suggested that the reactions proceed through the formation of α-aminoketones. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and simple operation. A gram-scale synthesis demonstrates the potential applications of the present method.
A simple and efficient approach to realize difunctionalization of arylketones with malonate esters via electrochemical oxidation
Gao, Huihui,Zha, Zhenggen,Zhang, Zhenlei,Ma, Huanyue,Wang, Zhiyong
, p. 5034 - 5036 (2014/05/06)
A facile difunctionalization of arylketones with malonate esters via electrochemical oxidation was achieved under mild conditions. A variety of difunctionalized products were obtained in good to excellent yields.
