160535-69-3

Upstream product

• 116-11-0 2-Methoxypropene 
• 132127-34-5 (3R,4S)-3-hydroxy-4-phenylazetidin-2-one 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 183133-96-2 carbazitaxel 
• 149107-92-6 (3R-cis)-1-benzoyl-3-(1-methoxy-1-methylethoxy)-4-phenyl-2-azetidinone 
• 182155-39-1 (3R,4S)-1-tert-butoxycarbonyl-3-[(triethylsilyl)oxy]-4-(phenyl)-3-methylazetidinone 
• 182155-38-0 (3R,4S)-1-Benzoyl-3-methyl-4-phenyl-3-triethylsilanyloxy-azetidin-2-one 
• 182155-37-9 (3R,4S)-3-[(triethylsilyl)oxy]-4-(phenyl)-3-methyl-azetidinone 
• 182155-28-8 (3R,4S)-1-(tert-Butyl-dimethyl-silanyl)-3-hydroxy-3-methyl-4-phenyl-azetidin-2-one 
• 182155-24-4 (3R,4S)-1-(tert-Butyl-dimethyl-silanyl)-3-hydroxy-4-phenyl-azetidin-2-one 
• 182155-26-6 (S)-1-(tert-Butyl-dimethyl-silanyl)-4-phenyl-azetidine-2,3-dione 
• 182155-36-8 (3R,4S)-3-hydroxy-3-methyl-4-phenyl-β-lactam 
• 182155-22-2 (3R,4S)-1-(tert-Butyl-dimethyl-silanyl)-3-(1-methoxy-1-methyl-ethoxy)-4-phenyl-azetidin-2-one 

Relevant academic research and scientific papers

A high-purity kaba he game process for the preparation of intermediate

The invention belongs to the technical field of drug synthesis, and particularly relates to a compound (2alpha, 5beta, 7beta, 10beta, 13alpha)-4-(acetyloxy)-13-({(2R, 3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-methoxy-2-prop-2-yl]oxy]-3-phenylpropionyl}oxy)-1,7,10-trimethoxy-9-oxo-5,20-epoxy-11-ene-2-yl benzoate (compound II, namely '7, 10, 13-trimethoxy-10-DAB'). The invention also relates to a preparation method of high-purity (2alpha, 5beta, 7beta, 10beta, 13alpha)-4-(acetyloxy)-13-({(2R, 3S)-3-[(tert-butoxycarbonyl)amino]-2-[2-methoxy-2-prop-2-yl]oxy]-3-phenylpropionyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxy-11-ene-2-yl benzoate (compound 1). The preparation method comprises the steps of silica gel chromatographic column chromatography and recrystallization. In the compound I prepared by the preparation method, the content of impurities compound II and compound III is remarkably reduced. The compounds I and III can be used for preparing an anti-cancer drug cabazitaxel.

β-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling β-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.

β-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling β-lactams to form such sidechain-bearing taxanes, and to

β-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes

Novel β-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling β-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.

Diastereoselective addition of grignard reagents to azetidine-23-dione: Synthesis of novel taxol analogues

Synthesis and cytotoxicity properties of novel C-2' analogues of paclitaxel are described. The analogues were synthesized using Holton's β-lactam approach to append the side chain on baccatin III. The key intermediate to the synthesis of novel analogues w