160625-35-4Relevant academic research and scientific papers
Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the σ1 receptor
Ronsisvalle, Giuseppe,Prezzavento, Orazio,Marrazzo, Agostino,Vittorio, Franco,Massimino, Michele,Murari, Giovanna,Spampinato, Santi
, p. 2662 - 2665 (2002)
(+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine (BNIT) (+)-(4) was designed and synthesized as a derivative of the potent and selective σ1 receptor ligand (+)-cis-N-benzyl-Nnormetazocine for irreversibly blocking σ1 binding sites.
(+)-cis-N-(Para-, meta-, and ortho-substituted benzyl)-N-normetazocines: Synthesis and binding affinity at the [3H]-(+)-pentazocine-labeled (σ1) site and quantitative structure-affinity relationship studies
Mascarella,Bai,Williams,Sine,Bowen,Carroll
, p. 565 - 569 (2007/10/02)
σ1 receptor ligands have potential pharmacological significance as antipsychotic drugs, as tools in the study of drug-induced motor function disorders, and as radiopharmaceutical imaging agents for the noninvasive imaging of malignant tumors in human subj
