Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the σ1 receptor

Article abstract of DOI:10.1021/jm010501a

(+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine (BNIT) (+)-(4) was designed and synthesized as a derivative of the potent and selective σ₁ receptor ligand (+)-cis-N-benzyl-Nnormetazocine for irreversibly blocking σ₁ binding sites.