160625-48-9Relevant academic research and scientific papers
Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A
Descamps, Aurelie,Furuie, Gaku,Hosoya, Takamitsu,Kii, Isao,Kikuchi, Masaki,Kimura, Ninako,Miyazaki, Yuka,Nakamura, Daichi,Niwa, Takashi,Saito, Kanako,Sumida, Tomoe,Sumida, Yuto,Umehara, Takashi,Umezawa, Koji
, (2021/11/09)
DYRK1A phosphorylates proteins involved in neurological disorders in an intermolecular manner. Meanwhile, during the protein folding process of DYRK1A, a transitional folding intermediate catalyzes the intramolecular autophosphorylation required for the “
SCREENING METHOD, PROTEIN INSTABILITY AND/OR STABILITY INDUCERS, AND PROTEIN ACTIVITY ASSESSMENT
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Paragraph 0132-0137, (2015/05/26)
Provided is a screening method with which it is possible to determine the cause of a decrease or an increase in the amount of a target protein that is expressed by a cell. One or a plurality of embodiments include: conducting cultivation that includes bri
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors
Jalily, Pouria H.,Hadfield, John A.,Hirst, Nicholas,Rossington, Steven B.
, p. 6731 - 6734 (2013/01/14)
A series of novel cyanocombretastatins bearing a 3,4,5-trimethoxyphenyl moiety combined with a variety of substituted phenyl rings, were synthesised and their antitumour activity was evaluated. The Z-cyanocombretastatins were synthesised in a one-step pro
Synthesis of new biheterocycles by a one-pot sonogashira coupling reaction
Deodhar, Mandar,Black, David Stc.,Kumar, Naresh
experimental part, p. 1489 - 1501 (2011/05/14)
Halogenated flavones, isoflavones and indoles were subjected to a one-pot Sonogashira coupling reaction to generate a series of new biheterocyclic compounds. The methodology can be readily adapted to the synthesis of a wide variety of substituted biheterocycles. The Japan Institute of Heterocyclic Chemistry.
An Alternative Route to a Benzofuran Natural Product Dehydrotremetone
Hiroya, Kou,Hashimura, Kazuya,Ogasawara, Kunio
, p. 2463 - 2472 (2007/10/02)
Dehydrotremetone, a toxic ketone isolated from the weeds Eupatorium urticaefolium and Aplopappus heterophyllus, has been synthesized from isovanillin via palladium-mediated cross-coupling reaction and lithium chloride-mediated concurrent demethylation-ben
