31823-05-9

Basic information

• Product Name: 1-BENZOFURAN-5-YLMETHANOL
• Synonyms: 1-BENZOFURAN-5-YLMETHANOL;RARECHEM AL BD 1369;Benzofuran-5-yl-Methanol
• CAS NO: 31823-05-9
• Molecular Formula: C9H8O2
• Molecular Weight: 148.16
• Product Categories: Furan&Benzofuran
• Mol File: 31823-05-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 35-36°C
• Boiling Point: 273.3 °C at 760 mmHg
• Flash Point: 119.1 °C
• Appearance: /
• Density: 1.233 g/cm³
• Vapor Pressure: 0.00282mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: 1-BENZOFURAN-5-YLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZOFURAN-5-YLMETHANOL(31823-05-9)
• EPA Substance Registry System: 1-BENZOFURAN-5-YLMETHANOL(31823-05-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 31823-05-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

InChI:InChI=1/C9H8O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-5,10H,6H2

Upstream product

• 10035-16-2 benzofuran-5-carbaldehyde 
• 127527-76-8 ethyl benzo[b]furan-5-carboxylate 
• 108763-47-9 5-(methoxycarbonyl)benzo[b]furan 
• 157790-73-3 4-methoxy-3-trifluoromethanesulfonyloxybenzaldehyde 
• 160625-48-9 4-methoxy-3-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 160625-49-0 3-ethynyl-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 

Downstream Products

• 1184869-53-1 (S)-benzofuran-5-ylmethyl 1-(diisobutylamino)-3-(4-((1,5-dimethyl-1H-pyrazol-3-yl)methoxy)phenyl)-1-oxopropan-2-ylcarbamate 
• 1185322-05-7 C₃₀H₃₂N₂O₅ 
• 1185322-03-5 C₃₉H₃₈N₂O₆ 

Relevant articles and documents

Efficient Water Reduction with sp3-sp3 Diboron(4) Compounds: Application to Hydrogenations, H–D Exchange Reactions, and Carbonyl Reductions

A series of crystalline sp3-sp3 diboron(4) compounds were synthesized and shown to promote the facile reduction of water with dihydrogen formation. The application of these diborons as simple and effective dihydrogen and dideuterium sources was demonstrated by conducting a series of selective reductions of alkynes and alkenes, and hydrogen–deuterium exchange reactions using two-chamber reactors. Finally, as the water reduction reaction generates an intermediate borohydride species, a range of aldehydes and ketones were reduced by using water as the hydride source.

Identification of MK-944a: A second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors

Recent results from human clinical trials have established the critical role of HIV protease inhibitors in the treatment of acquired immune-deficiency syndrome (AIDS). However, the emergence of viral resistance, demanding treatment protocols, and adverse side effects have exposed the urgent need for a second generation of HIV protease inhibitors. The continued exploration of our hydroxylaminepentanamide (HAPA) transition-state isostere series of HIV protease inhibitors, which initially resulted in the identification of Crixivan (indinavir sulfate, MK-639, L-735,524), has now yielded MK-944a (L-756,423). This compound is potent, is selective, and competitively inhibits HIV-1 PR with a K(i) value of 0.049 nM. It stops the spread of the HIV(IIIb)-infected MT4 lymphoid cells at 25.0-50.0 nM, even in the presence of α1 acid glycoprotein, human serum albumin, normal human serum, or fetal bovine serum. MK-944a has a longer half-life in several animal models (rats, dogs, and monkeys) than indinavir sulfate and is currently in advanced human clinical trials.

Alpha-aminoacyl-penicillins and cephalosporins

Antibacterially active and animal growth-regulating novel β-lactam compounds of the formula STR1 in which R1 represents an optionally substituted radical of the formula STR2 Z represents oxygen, sulphur or --N--R13, and A represents