16064-13-4

Basic information

• Product Name: 3-methyl-6-nitroquinazolin-4(3H)-one
• Synonyms: 4(3H)-quinazolinone, 3-methyl-6-nitro-
• CAS NO: 16064-13-4
• Molecular Formula: C₉H₇N₃O₃
• Molecular Weight: 205.1702
• Mol File: 16064-13-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 392.6°C at 760 mmHg
• Flash Point: 191.2°C
• Density: 1.48g/cm³
• Vapor Pressure: 2.27E-06mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 3-methyl-6-nitroquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-6-nitroquinazolin-4(3H)-one(16064-13-4)
• EPA Substance Registry System: 3-methyl-6-nitroquinazolin-4(3H)-one(16064-13-4)

Safety Data

• Hazardous Substances Data: 16064-13-4(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 6943-17-5 6-nitroquinazolone 
• 77-78-1 dimethyl sulfate 
• 123-39-7 N-Methylformamide 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 74-88-4 methyl iodide 
• 19815-16-8 4-chloro-6-nitro-quinazoline 
• 49675-68-5 4-amino-6-nitroquinazoline 
• 611-09-6 5-nitroisatin 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 16064-23-6 6-amino-3-methylquinazolin-4-one 
• 17329-31-6 6-amino-3H-quinazolin-4-one 

Relevant articles and documents

Synthesis and Cytotoxicity of Quinazolin-4(3H)-one Based Peptides

Abstract: A novel series of quinazolin-4(3H)-one derivatives has been synthesized in high yields using the multicomponent Ugi reaction and characterized by IR, NMR and mass spectral data. The products have been tested for their cytotoxic activity against HeLa cells. Two tested compounds have shown potent activity compared to standard drug Doxorubicin. The in silico docking studies of the compounds against quinone reductase-2 (4ZVM) enzyme have also supported their activity.

NEW BRAF INHIBITORS AS PARADOX BREAKERS

The invention provides a novel compound having the general formula (I) (I) wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.