16069-16-2

Upstream product

• 63-91-2 L-phenylalanine 
• 814-68-6 acryloyl chloride 

Downstream Products

• 1223582-21-5 (S)-N-acryloylphenylalanine-4-styrybenzyl ester 
• 1358017-45-4 (S)-N-(1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)acrylamide 
• 18939-41-8 (S)-methyl-2-acrylamido-3-phenylpropanoate 

Relevant academic research and scientific papers

Microwave-assisted graft copolymerization of amino acid based monomers onto starch and their use as drug carriers

This paper describes the synthesis of two amino acid-based monomer and their graft copolymerization onto starch and utilization of the prepared graft copolymers as drug carriers. The two monomers were synthesized and reacted with acryloyl chloride to get

Stimuli-responsive polymers based on L-phenylalanine residues: Protonation thermodynamics of free polymers and cross-linked hydrogels

Vinyl polymers carrying L-phenylalanine residues were synthesized in the free and in the cross-linked hydrogel form, as homo- and copolymers with N-isopropylacrylamide (NIPAAm). The protonation reaction thermodynamics of the COO- group were stu

Models for Use of α-Amino Acids as Chiral Auxiliaries in Asymmetric Diels-Alder Reactions

Three different models, depending on the Lewis acid used as a catalyst and the α-amino acid used as a chiral auxiliary, account for the diastereofacial selectivity obtained in reactions of cyclopentadiene with N-acryloyl derivatives of L-proline, L-phenylalanine, L-alanine, and N-methyl-L-alanine esters.For α-amino acids without an NH group and aluminum catalysts, a reactive conformer with antiplanar enoate conformation similar to those postulated for acrylates with only one center capable of coordination is proposed.These dienophiles form a chelate complex, where the acryloyl moiety is in syn conformation, with TiCl4.For α-amino acids with an NH group, a reactive intermediate with an antiplanar disposition in the acryloyl moiety and the conformation of the amino ester fixed by an intramolecular hydrogen bond accounts for the results with both kinds of catalyst.These models seem to have general application for the use of α-amino acids as chiral auxiliaries in asymmetric Diels-Alder reactions.

Abiotic Mimic of Endogenous Tissue Inhibitors of Metalloproteinases: Engineering Synthetic Polymer Nanoparticles for Use as a Broad-Spectrum Metalloproteinase Inhibitor

We describe a process for engineering a synthetic polymer nanoparticle (NP) that functions as an effective, broad-spectrum metalloproteinase inhibitor. Inhibition is achieved by incorporating three functional elements in the NP: a group that interacts with the catalytic zinc ion, functionality that enhances affinity to the substrate-binding pocket, and fine-tuning of the chemical composition of the polymer to strengthen NP affinity for the enzyme surface. The approach is validated by synthesis of a NP that sequesters and inhibits the proteolytic activity of snake venom metalloproteinases from five clinically relevant species of snakes. The mechanism of action of the NP mimics that of endogenous tissue inhibitors of metalloproteinases. The strategy provides a general design principle for synthesizing abiotic polymer inhibitors of enzymes.

Metal-Free Polymer-Based Affinity Medium for Selective Purification of His6-Tagged Proteins

We report a metal free synthetic hydrogel copolymer with affinity and selectivity for His6-tagged peptides and proteins. Small libraries of copolymers incorporating charged and hydrophobic functional groups were screened by an iterative process for His6 p

Anti-tumor composition carrying vincaleukoblastinum and preparation method thereof

The invention relates to an anti-tumor composition carrying vincaleukoblastinum. The composition is characterized in that the periphery of a vincaleukoblastinum molecule is wrapped with two bi-functional monomers through hydrogen bond connection, positive

HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE

This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

NEUTRALIZING VENOMOUS BIOMACROMOLECULES

The present invention relates generally to compositions and methods comprising abiotic, synthetic polymer nanoparticles (NPs) with affinity and specificity to peptide toxins, enzymes, signaling proteins and other large biomacromolecules. The synthetic pol

Synthesis and characterization of poly [N-acryloyl-(D/L),(+/-)- phenylalanine- -co-(D/L),(-/+)N-methacryloyloxyethyl- -N'-2-hydroxybutyl(urea)] copolymers

Two monomers of (D/L),(+/-)-N-methacryloyloxyethyl-N'-2-hydroxybutyl(urea) methacrylate (D/L-MABU) type were prepared and further polymerized through free radical polymerization with optically active monomers containing phenylalanine sequences such as N-a

Chiral recognition of macromolecules with cyclodextrins: pH- and thermosensitive copolymers from N-isopropylacrylamide and N-acryloyl-D/L- phenylalanine and their inclusion complexes with cyclodextrins

In the present work we report the enantioselective recognition of water soluble stimuli-responsive polymers bearing phenylalanine moieties via host-guest interaction with β-cyclodextrin and randomly-methylated-β- cyclodextrin (RAMEB-CD). We synthesised N-