160693-52-7

Upstream product

• 91348-51-5 1-(4-bromophenyl)-5-carbonylpyrrolidine-3-carboxylic acid 
• 97-65-4 2-methylenesuccinic acid 
• 106-40-1 4-bromo-aniline 
• 67-56-1 methanol 

Downstream Products

• 133749-56-1 1-(4-bromophenyl)-4-(hydroxymethyl)pyrrolidin-2-one 
• 1027950-13-5 [1-(4-bromophenyl)-5-oxo-pyrrolidin-3-yl]methyl methanesulfonate 
• 133749-57-2 Methyl 4-[1-(4-bromophenyl)-2-pyrrolidon-4-yl]methoxybenzoate 
• 1342800-33-2 N'-(3-methyl-4-oxo-1,4-dihydronaphthalen-1-ylidene)-1-(4-bromophenyl)-5-oxopyrrolidine-3-carbohydrazide 
• 1342800-44-5 N'-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-1-(4-bromophenyl)-5-oxopyrrolidine-3-carbohydrazid 
• 1342800-25-2 (4-bromophenyl)-5-oxo-N'-(4-oxo-1,4-dihydronaphthalen-1-ylidene)pyrrolidine-3-carbohydrazide 

Relevant academic research and scientific papers

LACTAMS AS INHIBITORS OF ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

Synthesis of 4-methyloxybenzoic acids and related compounds, and their inhibitory capacities toward fatty-acid and sterol biosynthesis

The synthesis of a series of 4-methyloxybenzoic acids and related compounds, and their evaluation for inhibitory capacity toward fatty-acid and sterol biosyntheses using rats' liver slices in vitro and rabbits