160694-77-9

Upstream product

• 7788-14-9 5-phenyl-1,2,4-oxadiazol-3-amine 
• 98-88-4 benzoyl chloride 
• 3166-01-6 N,N'-dibenzoylguanidine 
• 1009834-58-5 C₁₉H₂₁N₃OS 

Downstream Products

• 5378-59-6 2-(N-benzoyl)-amino-5-phenyl-[1,3,4]oxadiazole 
• 89879-91-4 3-benzamido-5-phenyl-1,2,4-thiadiazole 

Relevant academic research and scientific papers

Facile synthesis of 3-amino-5-aryl-1,2,4-oxadiazoles: Via PIDA-mediated intramolecular oxidative cyclization

A mild and efficient method for the synthesis of 3-amino-5-aryl-1,2,4-oxadiazole by intramolecular cyclization using PhI(OAc)2 (PIDA) as an oxidant is developed. Various 3-amino-5-aryl-1,2,4-oxadiazoles are prepared in moderate to good yields,

(3+2) annulation of amidinothioureas with binucleophile: Synthesis and antimicrobial activity of 3-phenylamino-5-aryl/alkyl-1,2, 4-oxadiazole derivatives

Herein, we report an efficient method for preparation of 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole by (3+2) annulation of amidinothioureas with binucleophilic hydroxylamine hydrochloride in the presence of mercury (II) chloride. Desired 3-phenylamino-5-aryl/alkyl-1,2,4-oxadiazole was prepared in good to moderate yields. On the basis of the literature precedence, the mechanism for the formation of 3-phenylamino- 5-aryl/alkyl-1,2,4-oxadiazole is proposed. The synthesized compounds were tested for their antimicrobial activity and showed promising inhibition of Gram-positive bacteria (Staphylococcus aureus) and fungi (Candida albicans).

NOVEL THERAPEUTIC COMPOUNDS

Disclosed herein are novel compounds of Formula (I), wherein the variables are defined as herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases as well as proliferative disorders such as cancer.

Molecular Rearrangements in Heterocyclic Synthesis. A Generalized Synthesis of 1,2,4-Thiadiazoles from 3-Acylamino-1-oxa-2-azoles

The sulfurization reaction of some 3-acylamino-1-oxa-2-azoles (1,2,4-oxadiazoles, isoxazoles and 1,2,5-oxadiazoles) with the Lawesson reagent has been investigated.A generalized methodology for the synthesis of 5-aryl-/alkyl-3-substituted 1,2,4-thiadiazol