1606991-97-2

Upstream product

• 960307-19-1 C₇H₁₁N₅S 
• 616-30-8 3-Amino-1,2-propanediol 
• 1606992-07-7 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzene-1-sulfonyl chloride 
• 682319-80-8 1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine 
• 871253-78-0 1,3-dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine 
• 1606992-08-8 1,3-dimethyl-5-phenylamino-1H-pyrazolo[4,3-e][1,2,4]triazine 

Relevant academic research and scientific papers

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine has been synthesized and characterized. Their anticancer activity was tested in vitro against multiple human cancer cell lines and were found to have dose-dependent antiproliferative effects. Furthermore, some of the new compounds inhibited the Abl protein kinase with low micromolar IC50 values and exhibited selective activity against the Bcr-Abl positive K562 and BV173 cell lines, providing starting points for the further development of this new kinase inhibitor scaffold.