1607005-69-5

Upstream product

• 876343-09-8 7-(benzenesulfonyl)-4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 
• 761446-44-0 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 252723-16-3 4-chloro-6-methyl-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 953040-54-5 1-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrole 
• 98-09-9 benzenesulfonyl chloride 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 186519-89-1 7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1607005-70-8 {2-fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]benzyl}methylcarbamic acid tert-butyl ester 

Relevant academic research and scientific papers

C-Kit inhibitor and application thereof

The invention discloses a C-Kit inhibitor compound shown by formula I and a stereoisomer or pharmaceutically acceptable salt thereof, wherein R1 is hydroxyl, cyano, C1-4 alkyl, halogen or halogen substituted C1-4 alkyl; R2 is hydrogen, hydroxyl, cyano, alkyl, halogen or halogen substituted C1-4 alkyl; R3 is hydrogen, hydroxyl, cyano, C1-4 alkyl, halogen or halogen substituted C1-4 alkyl. The invention also provides application of the compound and the stereoisomer or pharmaceutically acceptable salt thereof in preparing drugs for preventing or treating the diseases mediated by C-Kit, especiallymutant C-Kit. The formula I is shown in the description.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with exc