160701-51-9

Upstream product

• 13398-94-2 2-(3-hydroxyphenyl)ethanol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 943448-07-5 5-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-cyclohex-2-en-1-one 
• 160701-58-6 tert-butyldimethylsilyl 3-(2-hydroxyethyl)phenyl ether 

Relevant academic research and scientific papers

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)

Selective removal of phenolic and alcoholic silyl ethers

Potassium carbonate/Kriptofix 222 and pyridinium p-toluenesulfonate or BF3-etherate have been found to remove the tert-butyldimethylsilyl group from phenolic and alcoholic silyl ethers, respectively. This methodology should find wide applicability in complex organic synthesis.