160729-09-9

Upstream product

• 53744-27-7 3,4-dimethoxychalcone 
• 109-77-3 malononitrile 
• 2972-80-7 3,4-dimethoxybenzylidenemalononitrile 
• 98-86-2 acetophenone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 177900-50-4 2-Amino-4-(3,4-dimethoxy-phenyl)-6-phenyl-nicotinamide 

Relevant academic research and scientific papers

Experimental/computational assessments of API steel in 6 M H2SO4 medium containing novel pyridine derivatives as corrosion inhibitors

In this work, two pyridine derivatives were synthesized and explored their inhibitive influence on the API carbon steel corrosion in a 6 M H2SO4 solution. The compound was examined at different concentrations to optimized the best co

Ecofriendly synthesis of substituted pyridine and pyrido[2,3-d]pyrimidine derivatives

An environmentally benign novel one-pot synthesis of pyridines and pyrido[2,3-d]pyrimidines from chalcones and malononitrile was described. In the reaction under neat conditions using microwave irradiation, enhancement in the reaction rate and high yields

Iron(III) phosphate as a green and reusable catalyst for the synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles

Condensation reaction of aryl aldehydes, methyl ketones, malononitrile, and ammonium acetate in the presence of the green and recyclable catalyst FePO4 affords the corresponding 4,6-disubstituted 2-aminopyridine-3-carbonitriles. Some new derivatives of these compounds are synthesized. The catalyst can be also recycled and reused several times.

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2a adenosine receptor antagonists

A2A adenosine receptor antagonists usually have bi- or tricyclic N aromatic systems with varying substitution patterns to achieve desired receptor affinity and selectivity. Using a pharmacophore model designed by overlap of nonxanthine type of previously known A2A antagonists, we synthesized a new class of compounds having a 2-amino nicotinonitrile core moiety. From our data, we conclude that the presence of at least one furan group rather than phenyl is beneficial for high affinity on the A2A adenosine receptor. Compounds 39 (LUF6050) and 44 (LUF6080) of the series had Ki values of 1.4 and 1.0 nM, respectively, with reasonable selectivity toward the other adenosine receptor subtypes, A1, A 2B, and A3. The high affinity of 44 was corroborated in a cAMP second messenger assay, yielding subnanomolar potency for this compound.

Synthesis of some new pyrimidine bases as precursors of potential anticancer nucleosides

3,5,7-Trisubstituted-pyridopyrimidine-2,4(1H,3H)-diones (4) have been synthesized from the reaction of 2-amino-3-cyano-4,6-diarylpyridines (2) with arylisocyanates in dioxan-pyridine.Compounds 4 have also been prepared by the hydrolysis of 2 with alc.KOH to give 2-amino-3-carboxamido-4,6-disubstituted pyridines (3) which on refluxing with arylisocyanate in diphenyl ether afford 4.They are characterised by elemental analyses and IR and 1H NMR spectral data.They have been tested for antibacterial and antifungal activity.