16076-62-3

Usage

InChI:InChI=1/C14H24O3/c1-2-17-14(16)11-7-6-10-13(15)12-8-4-3-5-9-12/h12H,2-11H2,1H3

Upstream product

• 41302-32-3 ethyl 5-iodopentanoate 
• 10035-86-6 S-ethyl cyclohexanecarbothioate 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 109976-46-7 (5-ethoxy-5-oxopentyl)zinc(II) iodide 
• 110-83-8 cyclohexene 
• 1071701-59-1 6-cyclohex-1-enyl-6-oxo-hexanoic acid ethyl ester 

Downstream Products

• 854707-74-7 5-bromo-6-(1-bromo-cyclohexyl)-6-oxo-hexanoic acid 
• 20606-25-1 6-cyclohexyl-6-oxohexanoic acid 

Relevant academic research and scientific papers

Pd(OH)2/C (Pearlman's catalyst): A highly active catalyst for Fukuyama, Sonogashira, and Suzuki coupling reactions

Treatment of thiol esters 1 with zinc reagent 2 in the presence of a small amount (2/C (Pearlman's catalyst) provided functionalized asymmetrical ketones 3 in high yields. The use of Pd(OH)2/C was

A novel synthesis of functionalized ketones via a nickel-catalyzed coupling reaction of zinc reagents with thiolesters

Treatment of thiolesters with zinc reagents in the presence of Ni(acac)2 provided a variety of functionalized ketones in good yields. This new protocol was successfully applied to the synthesis of (+)-biotin to allow for a practical installation of the carboxybutyl chain.