41302-32-3

Basic information

• Product Name: ETHYL 5-IODOVALERATE
• Synonyms: ETHYL 5-IODOVALERATE;(Ethyl 5-iodopentanoate)
• CAS NO: 41302-32-3
• Molecular Formula: C₇H₁₃IO₂
• Molecular Weight: 256.08
• Product Categories: Acids & Esters;Iodine Compounds
• Mol File: 41302-32-3.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 222.1°C at 760 mmHg
• Flash Point: 88.1°C
• Appearance: /
• Density: 1.539g/cm³
• Vapor Pressure: 0.103mmHg at 25°C
• Refractive Index: 1.503
• CAS DataBase Reference: ETHYL 5-IODOVALERATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-IODOVALERATE(41302-32-3)
• EPA Substance Registry System: ETHYL 5-IODOVALERATE(41302-32-3)

Safety Data

• Hazardous Substances Data: 41302-32-3(Hazardous Substances Data)

Usage

Uses

Ethyl-5-iodovalerate is a reagent in the synthesis of 8-Amino-7-oxopelargonic Acid Hydrochloride (A618750) which is an intermediate in the synthesis of biotin. Pimeloyl-CoA is transformed into AOP in the presence of L-alanine by the enzyme AOP synthase. The catalytic mechanism of AOP synthase has been studied for the elucidation of inhibitors as potential antimicrobial agents.

InChI:InChI=1/C7H13IO2/c1-2-10-7(9)5-3-4-6-8/h2-6H2,1H3

Upstream product

• 2067-33-6 5-bromopentanoic acid 
• 64-17-5 ethanol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 2323-81-1 ethyl 5-chloropentanoate 
• 14660-52-7 ethyl 5-bromovalerate 
• 19448-36-3 5-iodopentanoic acid 

Downstream Products

• 16694-32-9 7-oxooctadecanoic acid 
• 333-67-5 5-Fluor-valeriansaeure-ethylester 
• 14274-15-8 2-phenyl-heptanedioic acid 
• 79181-99-0 triethyl 2-phenyl-2-carboxy-1,7-heptanedioate 
• 98300-44-8 ethyl N-(6-acetyl-3,4-dimethoxyphenyl)-5-aminopentanoate 
• 6337-68-4 ethyl 5-(4-acetyl)phenylpentanoate 
• 17734-38-2 ethyl 5-phenylpentanoate 
• 73301-37-8 1-methyl-4-(4-carbethoxybutyl)-cyclohexene 
• 92-52-4 biphenyl 
• 50628-92-7 ethyl 6-oxo-7-octenoate 
• 2136-76-7 (α-ketocyclopentylidene)triphenylphosphorane 
• 1407969-08-7 diethyl 5,5'-(6,6'-methylenebis(4-tert-butyl-2-(5-tert-butyl-2-(tertbutyldiphenylsilyloxy)benzyl)-6,1-phenylene)bis(oxy))dipentanoate 
• 1407969-12-3 ethyl 5-(4-tert-butyl-2-(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-6-(5-tert-butyl-3-(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-2-hydroxybenzyl)phenoxy)pentanoate 
• 1407968-98-2 ethyl 5-(2,6-bis(5-tert-butyl-2-(tert-butyldiphenylsilyloxy)benzyl)-4-tert-butylphenoxy)pentanoate 

Relevant articles and documents

Aminoglycoside hybrids as potent RNA antagonists

Aminoglycosides specifically bind to the A-site decoding region of prokaryotic 16S rRNA with dissociation constants in the 1-2 μM range. The aminoglycoside paromomycin binds to a truncated A-site construct with a K(d) = 1.85 μM. Paromomycin analogs are described here in which the aminoglycoside is linked via spacer groups to either thiazole orange or pyrene. These analogs bind specifically to the truncated A-site construct, but with affinities considerably higher than paromomycin itself. The binding of the hybrid molecules to the A-site is greater the shorter the spacer group.

PRODUCTION METHOD OF IODOALKANE DERIVATIVE USING MICROWAVE

PROBLEM TO BE SOLVED: To provide a production method of an iodoalkane derivative, with which the iodoalkane derivative can be produced even in a nonpolar solvent. SOLUTION: In a production method of a 5-iodovaleric acid ester, for example a 5-halogenovaleric acid ester represented by formula (1A) (in formula, R is a 1-6C alkyl group or a 7-11C aralkyl group and X is a chlorine atom or a bromine atom), is made to react with an alkali metal iodide salt by being brought into contact therewith in an organic solvent, in the presence of a tetrasubstituted ammonium salt, and further under microwave irradiation, in which 5-iodovaleric acid ester is represented by formula (3A), (in formula, R is synonymous with that in formula (1A)). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

The value of 2JP–CO as a diagnostic parameter for the structure and thermal reactivity of carbonyl-stabilised phosphonium ylides

A survey of 20 carbonyl-stabilised phosphonium ylides with recently reported X-ray structures shows a strong correlation between the C[dbnd]P to C[dbnd]O torsion angle and the value of 2JP–CO, with high values being associated with an anti configuration and low with syn. Seven new X-ray structural determinations are reported, several for types of ylide not crystallographically characterised before, and these also conform to this pattern. The value of 2JP–CO is then correlated with whether or not thermal extrusion of Ph3PO occurs to give alkynes for over 200 ylides and an empirical rule developed that the extrusion never occurs for ylides where this value is > 11 Hz. This is used to rationalise the anomalous behaviour of some trioxo ylides and cyclic ylides, two of which afford cycloalkynes, isolated after rearrangement as the isomeric 1,3-dienes. The rule also holds for a family of novel highly fluorinated ylides which afford fluorinated alkynes in good yield upon flash vacuum pyrolysis.

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues

A set of synthetic approaches was developed and applied to the synthesis of eight frame-shifted isoprenoid diphosphate analogues. These analogues were designed to increase or decrease the methylene units between the double bonds and/or the pyrophosphate m