16078-32-3Relevant academic research and scientific papers
Reactivity of stable neopentyl-Pd intermediates in the absence of nucleophile
Liron, Frédéric,Knochel, Paul
, p. 4943 - 4946 (2007)
In the absence of any trapping agent, stable neopentyl-Pd intermediates can terminate a catalytic cycle by undergoing a regioselective C-H activation, leading to various spiro or fused cyclopropane derivatives in a straightforward manner. If the neopentyl
Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)?H Bond Activation
Chung, Da Sol,Lee, Jae Sung,Ryu, Ho,Park, Jiyong,Kim, Hyunjoong,Lee, Joo Hyun,Kim, U Bin,Lee, Won Koo,Baik, Mu-Hyun,Lee, Sang-gi
, p. 15460 - 15464 (2018)
Reported is a tandem palladium-catalyzed Heck/regioselective C(sp3)?H activation reaction for the divergent synthesis of spiro- and fused-cyclopropanated indolines from N-methallylated 2-bromoarylamides. The regioselectivity of the C?H bond activation in the σ-alkylPdII intermediate is controlled by the solvent used. DFT calculations suggest that the polarity of solvent molecules could influence the transition-state energy, leading to a bifurcation of the C?H bond activation in the σ-alkylPdII intermediate.
