160801-26-3

Basic information

• Product Name: Docosahexaenoic Acid N-SucciniMide
• Synonyms: Docosahexaenoic Acid N-SucciniMide;AWUMFVFMQMCKHT-KUBAVDMBSA-N
• CAS NO: 160801-26-3
• Molecular Formula: C26H35NO4
• Molecular Weight: 425.5604
• Product Categories: Glycerols, Heterocycles, Fatty Acid Derivatives & Lipids
• Mol File: 160801-26-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 532.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Moisture Sensitive, Light Sensitive, Temperature Sensitive
• CAS DataBase Reference: Docosahexaenoic Acid N-SucciniMide(CAS DataBase Reference)
• NIST Chemistry Reference: Docosahexaenoic Acid N-SucciniMide(160801-26-3)
• EPA Substance Registry System: Docosahexaenoic Acid N-SucciniMide(160801-26-3)

Safety Data

• Hazardous Substances Data: 160801-26-3(Hazardous Substances Data)

Usage

Uses

Docosahexaenoic Acid N-Succinimide is the succinimide analog of Docosahexaenoic Acid (D494500) Omega-3 fatty acid found in marine fish oils and in many phospholipids. Major structural component of excitable membranes of the retina and brain; synthesized in the liver from α-linolenic acid. Nutritional supplement.

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 6217-54-5 docosahexaenoic acid 

Downstream Products

• 129024-87-9 (4Z,7Z,10Z,13Z,16Z,19Z)-N-(3,4-dihydroxyphenethyl)docosa-4,7,10,13,16,19-hexaenamide 

Relevant articles and documents

Unsaturated acyl chains dramatically enhanced cellular uptake by direct translocation of a minimalist oligo-arginine lipopeptide

The recurring issue with cell penetrating peptides is how to increase direct translocation vs. endocytosis, to avoid premature degradation. Acylation by a cis unsaturated chain (C22:6) of a short cationic peptide provides a new rational design to favour diffuse cytosolic and dense Golgi localisations.

STRUCTURED MOLECULAR VECTORS FOR ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF

The present invention relates to structured molecular vectors of formula (I), compounds of formula (II) and pharmaceutical compositions comprising such compounds. The invention also relates to such pharmaceutical compositions for use for preventing and/or treating a disease chosen among an inflammatory disease or a disease associated with a cognitive disorder. The invention further relates to such pharmaceutical compositions for use for preventing cognitive decline or restoring cognitive functions altered in brain injuries and/or in traumatic brain injuries and/or in a neuroinflammatory disease, and/or in a neurodegenerative disease.

Method of synthesizing acetonide-protected catechol-containing compounds and intermediates produced therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).