185454-47-1

Basic information

• Product Name: {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol
• Synonyms: {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol
• CAS NO: 185454-47-1
• Molecular Weight: 381.515
• Mol File: 185454-47-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol(185454-47-1)
• EPA Substance Registry System: {1-[3-(1,3-dioxolan-2-yl)prop-1-yl]piperidin-4-yl}diphenylmethanol(185454-47-1)

Safety Data

• Hazardous Substances Data: 185454-47-1(Hazardous Substances Data)

Upstream product

• 16686-11-6 2-(3-chloropropyl)-1,3-dioxolane 
• 115-46-8 C₁₈H₂₁NO 
• 160809-38-1 1-benzyl 4-ethyl piperidine-1,4-dicarboxylate 
• 96067-93-5 benzyl 4-(hydroxydiphenylmethyl)-piperidine-1-carboxylate 
• 1126-09-6 4-carbethoxypiperidine 

Downstream Products

• 83799-24-0 fexofenadine 
• 105955-84-8 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde 

Relevant articles and documents

Synthesis of terfenadine carboxylate

A synthesis of terfenadine carboxylate, 1, a metabolite of terfenadine 2, is described. In the key step, the sodium salt of 2-(4-bromo-phenyl)-2-methylpropionic acid, 7, was lithiated via a metal-halogen exchange using t-BuLi and subsequently condensed with 4-[4-(hydroxydiphenylmethylpiperidin-1-yl]butyraldehyde, 5, to afford terfenadine carboxylate, 1.